Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0893c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0892 and Rv0893c overlap by 23 nucleotidesRv0893c and Rv0894 are separated by 228 nucleotides Rv0892: Rv0892 - Probable monooxygenase, at 993,853 to 995,340 Rv0892 Rv0893c: Rv0893c - Possible S-adenosylmethionine-dependent methyltransferase, at 995,318 to 996,295 Rv0893c Rv0894: Rv0894 - Possible transcriptional regulatory protein (possibly LuxR-family), at 996,524 to 997,705 Rv0894 Position (kb) 995 996 997Strain fitness (log2 ratio) -1 0 1at 994.479 kb on + strand, within Rv0892at 994.547 kb on - strand, within Rv0892at 994.548 kb on + strand, within Rv0892at 994.555 kb on + strand, within Rv0892at 994.558 kb on - strand, within Rv0892at 995.198 kb on - strandat 995.271 kb on - strandat 995.319 kb on + strandat 995.345 kb on + strandat 995.388 kb on - strandat 995.420 kb on - strand, within Rv0893cat 995.867 kb on + strand, within Rv0893cat 996.105 kb on + strand, within Rv0893cat 996.510 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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994,479 + Rv0892 0.42 -1.0
994,547 - Rv0892 0.47 +1.6
994,548 + Rv0892 0.47 +1.4
994,555 + Rv0892 0.47 +1.0
994,558 - Rv0892 0.47 -1.1
995,198 - +0.5
995,271 - +0.1
995,319 + +0.3
995,345 + +1.2
995,388 - -0.7
995,420 - Rv0893c 0.10 +1.0
995,867 + Rv0893c 0.56 +0.4
996,105 + Rv0893c 0.80 -0.1
996,510 + -0.0

Or see this region's nucleotide sequence