Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0789c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0787A and Rv0788 overlap by 4 nucleotidesRv0788 and Rv0789c are separated by 16 nucleotidesRv0789c and Rv0790c are separated by 21 nucleotidesRv0790c and Rv0791c overlap by 4 nucleotides Rv0787A: Rv0787A - Conserved protein, at 882,524 to 882,763 Rv0787A Rv0788: Rv0788 - Probable phosphoribosylformylglycinamidine synthase I PURG (FGAM synthase I), at 882,760 to 883,434 Rv0788 Rv0789c: Rv0789c - Hypothetical protein, at 883,451 to 884,050 Rv0789c Rv0790c: Rv0790c - Hypothetical protein, at 884,072 to 884,800 Rv0790c Rv0791c: Rv0791c - Conserved protein, at 884,797 to 885,840 Rv0791c Position (kb) 883 884 885Strain fitness (log2 ratio) -2 -1 0 1at 883.493 kb on + strandat 883.493 kb on + strandat 883.728 kb on + strand, within Rv0789cat 883.782 kb on - strand, within Rv0789cat 883.875 kb on + strand, within Rv0789cat 884.150 kb on + strand, within Rv0790cat 884.151 kb on - strand, within Rv0790cat 884.232 kb on + strand, within Rv0790cat 884.232 kb on + strand, within Rv0790cat 884.376 kb on + strand, within Rv0790cat 884.376 kb on + strand, within Rv0790cat 884.376 kb on + strand, within Rv0790cat 884.376 kb on + strand, within Rv0790cat 884.376 kb on + strand, within Rv0790cat 884.377 kb on - strand, within Rv0790cat 884.632 kb on - strand, within Rv0790cat 884.649 kb on + strand, within Rv0790cat 884.649 kb on + strand, within Rv0790cat 884.650 kb on - strand, within Rv0790cat 884.652 kb on + strand, within Rv0790cat 884.653 kb on - strand, within Rv0790cat 884.655 kb on + strand, within Rv0790cat 884.655 kb on + strand, within Rv0790cat 884.656 kb on - strand, within Rv0790cat 884.745 kb on + strandat 884.745 kb on + strandat 884.746 kb on - strandat 884.859 kb on - strandat 884.859 kb on - strandat 884.918 kb on + strand, within Rv0791cat 884.919 kb on - strand, within Rv0791c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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883,493 + -2.4
883,493 + -0.4
883,728 + Rv0789c 0.46 +0.2
883,782 - Rv0789c 0.55 +0.5
883,875 + Rv0789c 0.71 -0.3
884,150 + Rv0790c 0.11 +0.6
884,151 - Rv0790c 0.11 +0.1
884,232 + Rv0790c 0.22 +0.9
884,232 + Rv0790c 0.22 -0.8
884,376 + Rv0790c 0.42 -0.6
884,376 + Rv0790c 0.42 -0.8
884,376 + Rv0790c 0.42 -0.7
884,376 + Rv0790c 0.42 -0.0
884,376 + Rv0790c 0.42 -0.4
884,377 - Rv0790c 0.42 -0.8
884,632 - Rv0790c 0.77 -0.6
884,649 + Rv0790c 0.79 -0.0
884,649 + Rv0790c 0.79 -0.0
884,650 - Rv0790c 0.79 +0.3
884,652 + Rv0790c 0.80 +0.2
884,653 - Rv0790c 0.80 +0.2
884,655 + Rv0790c 0.80 -0.1
884,655 + Rv0790c 0.80 +0.3
884,656 - Rv0790c 0.80 -0.8
884,745 + -0.3
884,745 + -0.1
884,746 - +0.1
884,859 - +0.0
884,859 - +0.3
884,918 + Rv0791c 0.12 -1.0
884,919 - Rv0791c 0.12 -0.5

Or see this region's nucleotide sequence