Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0407 and Rv0408 overlap by 8 nucleotides Rv0408 and Rv0409 overlap by 8 nucleotides
Rv0407: Rv0407 - F420-dependent glucose-6-phosphate dehydrogenase Fgd1, at 490,783 to 491,793
Rv0407
Rv0408: Rv0408 - Probable phosphate acetyltransferase Pta (phosphotransacetylase), at 491,786 to 493,858
Rv0408
Rv0409: Rv0409 - Probable acetate kinase AckA (acetokinase), at 493,851 to 495,008
Rv0409
Position (kb) 491
492
493
494 Strain fitness (log2 ratio) -1
0
1
2 at 490.799 kb on + strand at 490.804 kb on + strand at 490.804 kb on + strand at 490.805 kb on - strand at 490.805 kb on - strand at 491.196 kb on - strand, within Rv0407 at 491.245 kb on + strand, within Rv0407 at 491.300 kb on - strand, within Rv0407 at 491.390 kb on - strand, within Rv0407 at 491.486 kb on - strand, within Rv0407 at 491.673 kb on - strand, within Rv0407 at 491.680 kb on + strand, within Rv0407 at 491.681 kb on - strand, within Rv0407 at 491.681 kb on - strand, within Rv0407 at 491.982 kb on - strand at 492.359 kb on + strand, within Rv0408 at 492.360 kb on - strand, within Rv0408 at 492.435 kb on + strand, within Rv0408 at 492.869 kb on - strand, within Rv0408 at 492.888 kb on - strand, within Rv0408 at 493.356 kb on + strand, within Rv0408 at 493.357 kb on - strand, within Rv0408 at 493.364 kb on + strand, within Rv0408 at 493.700 kb on + strand at 493.806 kb on + strand at 493.807 kb on - strand at 494.287 kb on - strand, within Rv0409 at 494.358 kb on + strand, within Rv0409 at 494.359 kb on - strand, within Rv0409 at 494.359 kb on - strand, within Rv0409 at 494.557 kb on - strand, within Rv0409 at 494.666 kb on - strand, within Rv0409 at 494.745 kb on + strand, within Rv0409 at 494.852 kb on + strand, within Rv0409
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 490,799 + +1.0 490,804 + +2.0 490,804 + -1.2 490,805 - +1.3 490,805 - +2.6 491,196 - Rv0407 0.41 +2.3 491,245 + Rv0407 0.46 +2.1 491,300 - Rv0407 0.51 +2.0 491,390 - Rv0407 0.60 +1.9 491,486 - Rv0407 0.70 +1.0 491,673 - Rv0407 0.88 +2.1 491,680 + Rv0407 0.89 +2.0 491,681 - Rv0407 0.89 +2.1 491,681 - Rv0407 0.89 +1.0 491,982 - +0.1 492,359 + Rv0408 0.28 -0.6 492,360 - Rv0408 0.28 +0.0 492,435 + Rv0408 0.31 -0.6 492,869 - Rv0408 0.52 +0.5 492,888 - Rv0408 0.53 -0.1 493,356 + Rv0408 0.76 -0.0 493,357 - Rv0408 0.76 -1.4 493,364 + Rv0408 0.76 +0.4 493,700 + -0.3 493,806 + -0.2 493,807 - -0.3 494,287 - Rv0409 0.38 +0.4 494,358 + Rv0409 0.44 +1.0 494,359 - Rv0409 0.44 -0.6 494,359 - Rv0409 0.44 +0.0 494,557 - Rv0409 0.61 -0.2 494,666 - Rv0409 0.70 +0.0 494,745 + Rv0409 0.77 +2.3 494,852 + Rv0409 0.86 +0.1
Or see this region's nucleotide sequence