Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0405 and Rv0406c overlap by 53 nucleotides Rv0406c and Rv0407 are separated by 77 nucleotides
Rv0405: Rv0405 - Probable membrane bound polyketide synthase Pks6, at 485,731 to 489,939
Rv0405
Rv0406c: Rv0406c - Beta lactamase like protein, at 489,887 to 490,705
Rv0406c
Rv0407: Rv0407 - F420-dependent glucose-6-phosphate dehydrogenase Fgd1, at 490,783 to 491,793
Rv0407
Position (kb) 489
490
491 Strain fitness (log2 ratio) -1
0
1
2 at 488.903 kb on + strand, within Rv0405 at 488.903 kb on + strand, within Rv0405 at 488.903 kb on + strand, within Rv0405 at 488.903 kb on + strand, within Rv0405 at 488.904 kb on - strand, within Rv0405 at 488.908 kb on - strand, within Rv0405 at 488.915 kb on + strand, within Rv0405 at 488.916 kb on - strand, within Rv0405 at 488.933 kb on + strand, within Rv0405 at 488.934 kb on - strand, within Rv0405 at 488.989 kb on + strand, within Rv0405 at 489.005 kb on + strand, within Rv0405 at 489.532 kb on - strand at 489.535 kb on + strand at 489.535 kb on + strand at 489.536 kb on - strand at 489.680 kb on - strand at 489.937 kb on + strand at 490.064 kb on + strand, within Rv0406c at 490.064 kb on + strand, within Rv0406c at 490.065 kb on - strand, within Rv0406c at 490.143 kb on + strand, within Rv0406c at 490.144 kb on - strand, within Rv0406c at 490.144 kb on - strand, within Rv0406c at 490.282 kb on + strand, within Rv0406c at 490.370 kb on + strand, within Rv0406c at 490.390 kb on - strand, within Rv0406c at 490.488 kb on + strand, within Rv0406c at 490.488 kb on + strand, within Rv0406c at 490.758 kb on + strand at 490.759 kb on - strand at 490.765 kb on + strand at 490.766 kb on - strand at 490.766 kb on - strand at 490.771 kb on + strand at 490.771 kb on + strand at 490.772 kb on - strand at 490.772 kb on - strand at 490.772 kb on - strand at 490.799 kb on + strand at 490.804 kb on + strand at 490.804 kb on + strand at 490.805 kb on - strand at 490.805 kb on - strand at 491.196 kb on - strand, within Rv0407 at 491.245 kb on + strand, within Rv0407 at 491.300 kb on - strand, within Rv0407 at 491.390 kb on - strand, within Rv0407 at 491.486 kb on - strand, within Rv0407 at 491.673 kb on - strand, within Rv0407 at 491.680 kb on + strand, within Rv0407 at 491.681 kb on - strand, within Rv0407 at 491.681 kb on - strand, within Rv0407
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 488,903 + Rv0405 0.75 -0.5 488,903 + Rv0405 0.75 -0.0 488,903 + Rv0405 0.75 -0.0 488,903 + Rv0405 0.75 -0.4 488,904 - Rv0405 0.75 -0.6 488,908 - Rv0405 0.75 -0.2 488,915 + Rv0405 0.76 -0.2 488,916 - Rv0405 0.76 +1.0 488,933 + Rv0405 0.76 +0.1 488,934 - Rv0405 0.76 -0.3 488,989 + Rv0405 0.77 -0.7 489,005 + Rv0405 0.78 +0.6 489,532 - -0.0 489,535 + +1.0 489,535 + -0.3 489,536 - -0.1 489,680 - -0.1 489,937 + +0.1 490,064 + Rv0406c 0.22 +2.5 490,064 + Rv0406c 0.22 -0.5 490,065 - Rv0406c 0.22 +1.3 490,143 + Rv0406c 0.31 -0.3 490,144 - Rv0406c 0.31 +0.4 490,144 - Rv0406c 0.31 -0.6 490,282 + Rv0406c 0.48 -1.1 490,370 + Rv0406c 0.59 -0.2 490,390 - Rv0406c 0.61 -0.1 490,488 + Rv0406c 0.73 -0.1 490,488 + Rv0406c 0.73 -0.6 490,758 + +0.2 490,759 - +0.6 490,765 + -0.1 490,766 - +0.2 490,766 - +0.1 490,771 + -0.0 490,771 + -1.2 490,772 - +0.3 490,772 - +0.2 490,772 - +0.2 490,799 + +1.0 490,804 + +2.0 490,804 + -1.2 490,805 - +1.3 490,805 - +2.6 491,196 - Rv0407 0.41 +2.3 491,245 + Rv0407 0.46 +2.1 491,300 - Rv0407 0.51 +2.0 491,390 - Rv0407 0.60 +1.9 491,486 - Rv0407 0.70 +1.0 491,673 - Rv0407 0.88 +2.1 491,680 + Rv0407 0.89 +2.0 491,681 - Rv0407 0.89 +2.1 491,681 - Rv0407 0.89 +1.0
Or see this region's nucleotide sequence