Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0386 and Rv0387c are separated by 3 nucleotides Rv0387c and Rv0388c are separated by 52 nucleotides Rv0388c and Rv0389 are separated by 333 nucleotides
Rv0386: Rv0386 - Probable transcriptional regulatory protein (probably LuxR/UhpA-family), at 463,411 to 466,668
Rv0386
Rv0387c: Rv0387c - Conserved hypothetical protein, at 466,672 to 467,406
Rv0387c
Rv0388c: Rv0388c - PPE family protein PPE9, at 467,459 to 468,001
Rv0388c
Rv0389: Rv0389 - Probable phosphoribosylglycinamide formyltransferase 2 PurT (GART 2) (gar transformylase 2) (5'-phosphoribosylglycinamide transformylase 2) (formate-dependent gar transformylase), at 468,335 to 469,594
Rv0389
Position (kb) 466
467
468 Strain fitness (log2 ratio) -1
0
1 at 465.775 kb on + strand, within Rv0386 at 465.798 kb on + strand, within Rv0386 at 465.845 kb on - strand, within Rv0386 at 465.863 kb on - strand, within Rv0386 at 466.020 kb on + strand, within Rv0386 at 466.152 kb on + strand, within Rv0386 at 466.285 kb on - strand, within Rv0386 at 466.321 kb on + strand, within Rv0386 at 466.321 kb on + strand, within Rv0386 at 466.606 kb on + strand at 466.663 kb on - strand at 466.674 kb on - strand at 466.789 kb on + strand, within Rv0387c at 466.789 kb on + strand, within Rv0387c at 466.790 kb on - strand, within Rv0387c at 466.790 kb on - strand, within Rv0387c at 466.973 kb on + strand, within Rv0387c at 466.998 kb on + strand, within Rv0387c at 466.998 kb on + strand, within Rv0387c at 466.998 kb on + strand, within Rv0387c at 466.999 kb on - strand, within Rv0387c at 467.000 kb on + strand, within Rv0387c at 467.001 kb on - strand, within Rv0387c at 467.001 kb on - strand, within Rv0387c at 467.001 kb on - strand, within Rv0387c at 467.001 kb on - strand, within Rv0387c at 467.001 kb on - strand, within Rv0387c at 467.396 kb on - strand at 467.396 kb on - strand at 467.396 kb on - strand at 467.431 kb on + strand at 467.432 kb on - strand at 467.596 kb on + strand, within Rv0388c at 467.701 kb on - strand, within Rv0388c at 467.787 kb on + strand, within Rv0388c at 467.787 kb on + strand, within Rv0388c at 467.788 kb on - strand, within Rv0388c at 467.868 kb on + strand, within Rv0388c at 467.955 kb on + strand at 467.955 kb on + strand at 467.955 kb on + strand at 468.139 kb on + strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.140 kb on - strand at 468.143 kb on + strand at 468.143 kb on + strand at 468.185 kb on - strand at 468.247 kb on + strand at 468.296 kb on + strand at 468.296 kb on + strand at 468.296 kb on + strand at 468.296 kb on + strand at 468.297 kb on - strand
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 465,775 + Rv0386 0.73 -0.2 465,798 + Rv0386 0.73 -0.2 465,845 - Rv0386 0.75 -0.2 465,863 - Rv0386 0.75 -0.7 466,020 + Rv0386 0.80 +0.1 466,152 + Rv0386 0.84 -0.5 466,285 - Rv0386 0.88 +0.5 466,321 + Rv0386 0.89 +0.7 466,321 + Rv0386 0.89 -0.1 466,606 + -0.1 466,663 - +1.0 466,674 - +0.2 466,789 + Rv0387c 0.16 -0.4 466,789 + Rv0387c 0.16 -1.0 466,790 - Rv0387c 0.16 -1.1 466,790 - Rv0387c 0.16 -0.3 466,973 + Rv0387c 0.41 -0.4 466,998 + Rv0387c 0.44 -0.5 466,998 + Rv0387c 0.44 -0.3 466,998 + Rv0387c 0.44 -0.3 466,999 - Rv0387c 0.44 -0.0 467,000 + Rv0387c 0.45 -0.2 467,001 - Rv0387c 0.45 -0.2 467,001 - Rv0387c 0.45 -1.7 467,001 - Rv0387c 0.45 -1.2 467,001 - Rv0387c 0.45 +0.0 467,001 - Rv0387c 0.45 -0.0 467,396 - +0.5 467,396 - -0.0 467,396 - +0.6 467,431 + -0.1 467,432 - -0.1 467,596 + Rv0388c 0.25 +0.1 467,701 - Rv0388c 0.45 +0.4 467,787 + Rv0388c 0.60 +0.1 467,787 + Rv0388c 0.60 -0.4 467,788 - Rv0388c 0.61 -0.1 467,868 + Rv0388c 0.75 -0.1 467,955 + -0.2 467,955 + +0.1 467,955 + -0.1 468,139 + -0.6 468,140 - +1.0 468,140 - -0.1 468,140 - +0.3 468,140 - +0.7 468,140 - -0.4 468,140 - +0.4 468,140 - -0.1 468,143 + +0.1 468,143 + -1.0 468,185 - -0.4 468,247 + -0.3 468,296 + -0.0 468,296 + -0.3 468,296 + -0.3 468,296 + -0.3 468,297 - -0.3
Or see this region's nucleotide sequence