Experiment: 7H9 with Delamanid 0.236 ug/mL
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Rv0276 and Rv0277c are separated by 39 nucleotides Rv0277c and Rv0277A are separated by 23 nucleotides Rv0277A and Rv0278c are separated by 19 nucleotides Rv0278c and Rv0279c are separated by 249 nucleotides
Rv0276: Rv0276 - Conserved hypothetical protein, at 331,748 to 332,668
Rv0276
Rv0277c: Rv0277c - Possible toxin VapC25. Contains PIN domain., at 332,708 to 333,136
Rv0277c
Rv0277A: Rv0277A - Possible antitoxin VapB25, at 333,160 to 333,417
Rv0277A
Rv0278c: Rv0278c - PE-PGRS family protein PE_PGRS3, at 333,437 to 336,310
Rv0278c
Rv0279c: Rv0279c - PE-PGRS family protein PE_PGRS4, at 336,560 to 339,073
Rv0279c
Position (kb) 333
334
335
336
337 Strain fitness (log2 ratio) -2
-1
0
1
2 at 332.666 kb on + strand at 332.710 kb on - strand at 332.725 kb on + strand at 332.725 kb on + strand at 332.725 kb on + strand at 332.726 kb on - strand at 333.011 kb on + strand, within Rv0277c at 333.011 kb on + strand, within Rv0277c at 333.012 kb on - strand, within Rv0277c at 333.012 kb on - strand, within Rv0277c at 333.012 kb on - strand, within Rv0277c at 333.012 kb on - strand, within Rv0277c at 333.141 kb on + strand at 333.141 kb on + strand at 333.141 kb on + strand at 333.142 kb on - strand at 333.142 kb on - strand at 333.214 kb on - strand, within Rv0277A at 333.224 kb on - strand, within Rv0277A at 333.224 kb on - strand, within Rv0277A at 333.224 kb on - strand, within Rv0277A at 333.232 kb on - strand, within Rv0277A at 333.232 kb on - strand, within Rv0277A at 333.386 kb on - strand, within Rv0277A at 333.430 kb on - strand at 333.438 kb on + strand at 333.439 kb on - strand at 333.503 kb on + strand at 333.503 kb on + strand at 333.905 kb on + strand, within Rv0278c at 333.905 kb on + strand, within Rv0278c at 333.906 kb on - strand, within Rv0278c at 333.999 kb on - strand, within Rv0278c at 333.999 kb on - strand, within Rv0278c at 333.999 kb on - strand, within Rv0278c at 334.470 kb on - strand, within Rv0278c at 335.679 kb on - strand, within Rv0278c at 335.681 kb on + strand, within Rv0278c at 335.682 kb on - strand, within Rv0278c at 336.051 kb on + strand at 336.382 kb on + strand at 336.383 kb on - strand at 336.452 kb on - strand at 336.561 kb on + strand at 336.561 kb on + strand at 336.562 kb on - strand at 336.896 kb on + strand, within Rv0279c at 336.896 kb on + strand, within Rv0279c at 336.896 kb on + strand, within Rv0279c at 336.896 kb on + strand, within Rv0279c at 336.897 kb on - strand, within Rv0279c at 336.897 kb on - strand, within Rv0279c at 336.897 kb on - strand, within Rv0279c at 336.947 kb on + strand, within Rv0279c at 336.947 kb on + strand, within Rv0279c at 336.948 kb on - strand, within Rv0279c at 337.223 kb on - strand, within Rv0279c
Per-strain Table
Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL remove 332,666 + +0.1 332,710 - -1.0 332,725 + -0.4 332,725 + +0.4 332,725 + +0.3 332,726 - -0.7 333,011 + Rv0277c 0.71 +0.0 333,011 + Rv0277c 0.71 -0.5 333,012 - Rv0277c 0.71 -1.0 333,012 - Rv0277c 0.71 +0.0 333,012 - Rv0277c 0.71 -0.3 333,012 - Rv0277c 0.71 -0.6 333,141 + -0.9 333,141 + +0.1 333,141 + -0.0 333,142 - -0.2 333,142 - +1.7 333,214 - Rv0277A 0.21 -0.4 333,224 - Rv0277A 0.25 +2.0 333,224 - Rv0277A 0.25 -1.8 333,224 - Rv0277A 0.25 -0.4 333,232 - Rv0277A 0.28 -1.6 333,232 - Rv0277A 0.28 -2.0 333,386 - Rv0277A 0.88 +1.6 333,430 - +0.6 333,438 + -0.6 333,439 - -0.3 333,503 + +0.3 333,503 + -0.1 333,905 + Rv0278c 0.16 +0.0 333,905 + Rv0278c 0.16 -0.1 333,906 - Rv0278c 0.16 +0.2 333,999 - Rv0278c 0.20 -0.6 333,999 - Rv0278c 0.20 +0.7 333,999 - Rv0278c 0.20 +0.2 334,470 - Rv0278c 0.36 +1.5 335,679 - Rv0278c 0.78 +0.3 335,681 + Rv0278c 0.78 +1.5 335,682 - Rv0278c 0.78 +0.3 336,051 + +0.5 336,382 + +2.0 336,383 - -0.2 336,452 - -0.2 336,561 + -0.3 336,561 + +1.3 336,562 - -0.9 336,896 + Rv0279c 0.13 -0.0 336,896 + Rv0279c 0.13 -1.4 336,896 + Rv0279c 0.13 -0.4 336,896 + Rv0279c 0.13 +0.0 336,897 - Rv0279c 0.13 -1.1 336,897 - Rv0279c 0.13 +0.1 336,897 - Rv0279c 0.13 +0.1 336,947 + Rv0279c 0.15 -0.2 336,947 + Rv0279c 0.15 -0.1 336,948 - Rv0279c 0.15 +0.0 337,223 - Rv0279c 0.26 +0.2
Or see this region's nucleotide sequence