Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3740c

Experiment: 7H9 with Delamanid 0.236 ug/mL

Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

Per-strain Table

Position	Strand	Gene	LocusTag	Fraction	7H9 with Delamanid 0.236 ug/mL
4,189,842	-		Rv3738c	0.59	-1.0
4,189,842	-		Rv3738c	0.59	-0.4
4,190,048	+		Rv3738c	0.80	+0.1
4,190,048	+		Rv3738c	0.80	-0.2
4,190,049	-		Rv3738c	0.81	-0.9
4,190,049	-		Rv3738c	0.81	-0.4
4,190,049	-		Rv3738c	0.81	-0.8
4,190,049	-		Rv3738c	0.81	-1.0
4,190,052	+		Rv3738c	0.81	-0.2
4,190,052	+		Rv3738c	0.81	-0.0
4,190,052	+		Rv3738c	0.81	-0.2
4,190,052	+		Rv3738c	0.81	+0.4
4,190,052	+		Rv3738c	0.81	+0.3
4,190,052	+		Rv3738c	0.81	+0.6
4,190,052	+		Rv3738c	0.81	-0.9
4,190,053	-		Rv3738c	0.81	-0.4
4,190,090	+		Rv3738c	0.85	+0.4
4,190,091	-		Rv3738c	0.85	+0.8
4,190,091	-		Rv3738c	0.85	+0.4
4,190,122	-		Rv3738c	0.88	+0.1
4,190,173	-				-0.3
4,190,219	+				-0.9
4,190,219	+				-2.5
4,190,232	+				+0.6
4,190,233	-				-0.0
4,190,315	+		Rv3739c	0.13	+0.4
4,190,315	+		Rv3739c	0.13	-0.2
4,190,315	+		Rv3739c	0.13	-0.2
4,190,315	+		Rv3739c	0.13	-0.3
4,190,316	-		Rv3739c	0.14	-0.7
4,190,316	-		Rv3739c	0.14	-0.8
4,190,316	-		Rv3739c	0.14	-0.3
4,190,316	-		Rv3739c	0.14	+1.5
4,190,316	-		Rv3739c	0.14	+0.1
4,190,316	-		Rv3739c	0.14	-0.0
4,190,353	+		Rv3739c	0.29	-0.3
4,190,396	+		Rv3739c	0.48	-0.3
4,190,517	+				+0.4
4,190,517	+				+0.2
4,190,517	+				-0.4
4,190,530	+				-0.2
4,190,583	+				-0.1
4,190,584	-				-1.1
4,190,584	-				-0.4
4,190,584	-				-0.6
4,190,605	-				-1.2
4,190,605	-				-0.4
4,190,690	-				-0.6
4,190,762	+				+1.1
4,190,762	+				-0.6
4,190,763	-				-0.2
4,190,763	-				-0.1
4,190,763	-				-0.2
4,190,763	-				+0.3
4,190,763	-				+0.3
4,190,773	-				-0.4
4,190,786	-				+2.7
4,191,006	-		Rv3740c	0.13	-0.0
4,191,035	+		Rv3740c	0.15	-0.3
4,191,078	+		Rv3740c	0.18	-0.5
4,191,184	+		Rv3740c	0.26	+0.2
4,191,188	-		Rv3740c	0.26	-0.2
4,191,188	-		Rv3740c	0.26	-0.2
4,191,195	+		Rv3740c	0.27	-0.0
4,191,195	+		Rv3740c	0.27	+1.0
4,191,195	+		Rv3740c	0.27	+0.0
4,191,196	-		Rv3740c	0.27	+0.0
4,191,196	-		Rv3740c	0.27	+0.6
4,191,196	-		Rv3740c	0.27	+0.0
4,191,198	+		Rv3740c	0.27	-0.7
4,191,744	+		Rv3740c	0.68	-0.0
4,191,744	+		Rv3740c	0.68	-0.2
4,191,745	-		Rv3740c	0.68	-0.0
4,191,788	+		Rv3740c	0.71	-0.5
4,191,788	+		Rv3740c	0.71	-0.1
4,191,788	+		Rv3740c	0.71	+0.9
4,192,022	-		Rv3740c	0.88	-0.7
4,192,030	+		Rv3740c	0.89	+2.2
4,192,031	-		Rv3740c	0.89	-1.1
4,192,031	-		Rv3740c	0.89	+1.0
4,192,153	+				+1.5
4,192,153	+				+0.3
4,192,154	-				+0.0
4,192,245	-				+0.4
4,192,581	-		Rv3741c	0.60	-1.6
4,192,779	+		Rv3741c	0.89	-1.2
4,192,832	-				+1.0
4,192,849	-				+0.8
4,193,067	+		Rv3742c	0.55	-0.9
4,193,067	+		Rv3742c	0.55	-0.0
4,193,068	-		Rv3742c	0.55	-0.2
4,193,068	-		Rv3742c	0.55	-0.7
4,193,156	+		Rv3742c	0.77	+1.5
4,193,156	+		Rv3742c	0.77	+0.4
4,193,157	-		Rv3742c	0.78	+0.1
4,193,160	+		Rv3742c	0.78	-0.0
4,193,161	-		Rv3742c	0.79	-0.0
4,193,161	-		Rv3742c	0.79	+0.1
4,193,161	-		Rv3742c	0.79	+0.1
4,193,163	+		Rv3742c	0.79	+0.1
4,193,163	+		Rv3742c	0.79	+0.1
4,193,164	-		Rv3742c	0.79	-0.1
4,193,164	-		Rv3742c	0.79	-0.7