Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2239c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2237 and Rv2237A are separated by 94 nucleotidesRv2237A and GFF2321 are separated by 10 nucleotidesGFF2321 and Rv2238c are separated by 45 nucleotidesRv2238c and Rv2239c overlap by 1 nucleotidesRv2239c and Rv2240c are separated by 37 nucleotidesRv2240c and Rv2241 are separated by 258 nucleotides Rv2237: Rv2237 - Conserved protein, at 2,509,489 to 2,510,256 Rv2237 Rv2237A: Rv2237A - Conserved protein, at 2,510,351 to 2,510,587 Rv2237A GFF2321 - tRNA-Val, at 2,510,598 to 2,510,669 GFF2321 Rv2238c: Rv2238c - Probable peroxiredoxin AhpE, at 2,510,715 to 2,511,176 Rv2238c Rv2239c: Rv2239c - Conserved hypothetical protein, at 2,511,176 to 2,511,652 Rv2239c Rv2240c: Rv2240c - Unknown protein, at 2,511,690 to 2,512,280 Rv2240c Rv2241: Rv2241 - Pyruvate dehydrogenase E1 component AceE (pyruvate decarboxylase) (pyruvate dehydrogenase) (pyruvic dehydrogenase), at 2,512,539 to 2,515,244 Rv2241 Position (kb) 2511 2512Strain fitness (log2 ratio) -2 -1 0 1at 2510.207 kb on - strandat 2510.437 kb on - strand, within Rv2237Aat 2510.437 kb on - strand, within Rv2237Aat 2510.592 kb on - strandat 2510.724 kb on - strandat 2511.820 kb on + strand, within Rv2240cat 2511.820 kb on + strand, within Rv2240cat 2511.821 kb on - strand, within Rv2240cat 2512.407 kb on + strandat 2512.407 kb on + strandat 2512.407 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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2,510,207 - -1.1
2,510,437 - Rv2237A 0.36 +0.3
2,510,437 - Rv2237A 0.36 +0.2
2,510,592 - -0.1
2,510,724 - -0.3
2,511,820 + Rv2240c 0.22 +0.9
2,511,820 + Rv2240c 0.22 -2.6
2,511,821 - Rv2240c 0.22 -0.8
2,512,407 + -0.7
2,512,407 + -0.2
2,512,407 + +0.6

Or see this region's nucleotide sequence