Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1257c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1256c and Rv1257c are separated by 113 nucleotidesRv1257c and Rv1258c overlap by 4 nucleotides Rv1256c: Rv1256c - Probable cytochrome P450 130 Cyp130, at 1,403,386 to 1,404,603 Rv1256c Rv1257c: Rv1257c - Probable oxidoreductase, at 1,404,717 to 1,406,084 Rv1257c Rv1258c: Rv1258c - Probable conserved integral membrane transport protein, at 1,406,081 to 1,407,340 Rv1258c Position (kb) 1404 1405 1406 1407Strain fitness (log2 ratio) -2 -1 0 1 2 3at 1403.905 kb on + strand, within Rv1256cat 1404.141 kb on - strand, within Rv1256cat 1404.176 kb on - strand, within Rv1256cat 1404.464 kb on + strand, within Rv1256cat 1404.464 kb on + strand, within Rv1256cat 1404.467 kb on + strand, within Rv1256cat 1404.468 kb on - strand, within Rv1256cat 1404.474 kb on - strand, within Rv1256cat 1404.805 kb on + strandat 1404.944 kb on - strand, within Rv1257cat 1405.596 kb on + strand, within Rv1257cat 1405.596 kb on + strand, within Rv1257cat 1405.597 kb on - strand, within Rv1257cat 1405.597 kb on - strand, within Rv1257cat 1405.601 kb on - strand, within Rv1257cat 1405.619 kb on - strand, within Rv1257cat 1405.747 kb on + strand, within Rv1257cat 1405.748 kb on - strand, within Rv1257cat 1406.017 kb on + strandat 1406.298 kb on - strand, within Rv1258cat 1406.334 kb on - strand, within Rv1258cat 1406.334 kb on - strand, within Rv1258cat 1406.340 kb on + strand, within Rv1258cat 1406.340 kb on + strand, within Rv1258cat 1406.341 kb on - strand, within Rv1258cat 1406.341 kb on - strand, within Rv1258cat 1406.341 kb on - strand, within Rv1258cat 1406.344 kb on + strand, within Rv1258cat 1406.344 kb on + strand, within Rv1258cat 1406.345 kb on - strand, within Rv1258cat 1406.345 kb on - strand, within Rv1258cat 1406.345 kb on - strand, within Rv1258cat 1406.347 kb on - strand, within Rv1258cat 1406.347 kb on - strand, within Rv1258cat 1406.367 kb on + strand, within Rv1258cat 1406.368 kb on - strand, within Rv1258cat 1406.508 kb on + strand, within Rv1258cat 1406.626 kb on - strand, within Rv1258cat 1406.626 kb on - strand, within Rv1258cat 1406.812 kb on + strand, within Rv1258cat 1406.813 kb on - strand, within Rv1258cat 1406.878 kb on + strand, within Rv1258cat 1406.878 kb on + strand, within Rv1258c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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1,403,905 + Rv1256c 0.43 -0.9
1,404,141 - Rv1256c 0.62 -0.2
1,404,176 - Rv1256c 0.65 -0.5
1,404,464 + Rv1256c 0.89 -2.1
1,404,464 + Rv1256c 0.89 +0.5
1,404,467 + Rv1256c 0.89 +0.5
1,404,468 - Rv1256c 0.89 +0.1
1,404,474 - Rv1256c 0.89 -0.0
1,404,805 + -0.1
1,404,944 - Rv1257c 0.17 -0.3
1,405,596 + Rv1257c 0.64 -0.2
1,405,596 + Rv1257c 0.64 -0.4
1,405,597 - Rv1257c 0.64 +0.4
1,405,597 - Rv1257c 0.64 -0.2
1,405,601 - Rv1257c 0.65 -0.0
1,405,619 - Rv1257c 0.66 +0.1
1,405,747 + Rv1257c 0.75 -0.4
1,405,748 - Rv1257c 0.75 +0.2
1,406,017 + +1.6
1,406,298 - Rv1258c 0.17 +1.8
1,406,334 - Rv1258c 0.20 +1.7
1,406,334 - Rv1258c 0.20 +0.2
1,406,340 + Rv1258c 0.21 -0.4
1,406,340 + Rv1258c 0.21 -0.6
1,406,341 - Rv1258c 0.21 -0.4
1,406,341 - Rv1258c 0.21 -0.1
1,406,341 - Rv1258c 0.21 -0.2
1,406,344 + Rv1258c 0.21 -0.0
1,406,344 + Rv1258c 0.21 +1.9
1,406,345 - Rv1258c 0.21 +0.9
1,406,345 - Rv1258c 0.21 -0.2
1,406,345 - Rv1258c 0.21 -0.1
1,406,347 - Rv1258c 0.21 +0.3
1,406,347 - Rv1258c 0.21 -0.2
1,406,367 + Rv1258c 0.23 -1.0
1,406,368 - Rv1258c 0.23 -0.4
1,406,508 + Rv1258c 0.34 +0.2
1,406,626 - Rv1258c 0.43 -0.3
1,406,626 - Rv1258c 0.43 -1.0
1,406,812 + Rv1258c 0.58 -0.1
1,406,813 - Rv1258c 0.58 -1.2
1,406,878 + Rv1258c 0.63 -0.2
1,406,878 + Rv1258c 0.63 +3.2

Or see this region's nucleotide sequence