Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0975c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0974c and Rv0975c are separated by 2 nucleotidesRv0975c and Rv0976c overlap by 4 nucleotides Rv0974c: Rv0974c - Probable acetyl-/propionyl-CoA carboxylase (beta subunit) AccD2, at 1,085,756 to 1,087,345 Rv0974c Rv0975c: Rv0975c - Probable acyl-CoA dehydrogenase FadE13, at 1,087,348 to 1,088,496 Rv0975c Rv0976c: Rv0976c - Conserved hypothetical protein, at 1,088,493 to 1,090,175 Rv0976c Position (kb) 1087 1088 1089Strain fitness (log2 ratio) -1 0 1at 1087.466 kb on + strand, within Rv0975cat 1087.467 kb on - strand, within Rv0975cat 1087.604 kb on + strand, within Rv0975cat 1088.027 kb on + strand, within Rv0975cat 1088.027 kb on + strand, within Rv0975cat 1088.028 kb on - strand, within Rv0975cat 1088.083 kb on + strand, within Rv0975cat 1088.084 kb on - strand, within Rv0975cat 1088.240 kb on + strand, within Rv0975cat 1088.241 kb on - strand, within Rv0975cat 1088.241 kb on - strand, within Rv0975cat 1088.691 kb on + strand, within Rv0976cat 1088.742 kb on + strand, within Rv0976cat 1089.310 kb on + strand, within Rv0976cat 1089.311 kb on - strand, within Rv0976c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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1,087,466 + Rv0975c 0.10 +0.9
1,087,467 - Rv0975c 0.10 +0.4
1,087,604 + Rv0975c 0.22 +0.1
1,088,027 + Rv0975c 0.59 +0.3
1,088,027 + Rv0975c 0.59 +0.9
1,088,028 - Rv0975c 0.59 -0.1
1,088,083 + Rv0975c 0.64 +0.3
1,088,084 - Rv0975c 0.64 +0.2
1,088,240 + Rv0975c 0.78 +1.5
1,088,241 - Rv0975c 0.78 -0.1
1,088,241 - Rv0975c 0.78 -0.7
1,088,691 + Rv0976c 0.12 +0.2
1,088,742 + Rv0976c 0.15 +0.1
1,089,310 + Rv0976c 0.49 -0.3
1,089,311 - Rv0976c 0.49 -0.0

Or see this region's nucleotide sequence