Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0967

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0965c and Rv0966c are separated by 35 nucleotidesRv0966c and Rv0967 are separated by 139 nucleotidesRv0967 and Rv0968 are separated by 56 nucleotidesRv0968 and Rv0969 are separated by 55 nucleotides Rv0965c: Rv0965c - Conserved hypothetical protein, at 1,076,778 to 1,077,197 Rv0965c Rv0966c: Rv0966c - Conserved protein, at 1,077,233 to 1,077,835 Rv0966c Rv0967: Rv0967 - Copper-sensitive operon repressor CsoR, at 1,077,975 to 1,078,334 Rv0967 Rv0968: Rv0968 - Conserved protein, at 1,078,391 to 1,078,687 Rv0968 Rv0969: Rv0969 - Probable metal cation transporter P-type ATPase CtpV, at 1,078,743 to 1,081,055 Rv0969 Position (kb) 1077 1078 1079Strain fitness (log2 ratio) -2 -1 0 1 2at 1077.121 kb on + strand, within Rv0965cat 1077.121 kb on + strand, within Rv0965cat 1077.122 kb on - strand, within Rv0965cat 1077.122 kb on - strand, within Rv0965cat 1077.617 kb on + strand, within Rv0966cat 1077.618 kb on - strand, within Rv0966cat 1077.663 kb on + strand, within Rv0966cat 1077.678 kb on + strand, within Rv0966cat 1077.702 kb on + strand, within Rv0966cat 1077.848 kb on + strandat 1077.849 kb on - strandat 1077.849 kb on - strandat 1077.963 kb on + strandat 1077.963 kb on + strandat 1077.963 kb on + strandat 1077.964 kb on - strandat 1078.372 kb on + strandat 1078.533 kb on + strand, within Rv0968at 1078.534 kb on - strand, within Rv0968at 1078.534 kb on - strand, within Rv0968at 1078.540 kb on - strand, within Rv0968at 1079.030 kb on - strand, within Rv0969at 1079.188 kb on + strand, within Rv0969

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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1,077,121 + Rv0965c 0.82 -1.9
1,077,121 + Rv0965c 0.82 -1.2
1,077,122 - Rv0965c 0.82 -0.3
1,077,122 - Rv0965c 0.82 -0.6
1,077,617 + Rv0966c 0.64 +0.2
1,077,618 - Rv0966c 0.64 -0.4
1,077,663 + Rv0966c 0.71 +0.3
1,077,678 + Rv0966c 0.74 -0.5
1,077,702 + Rv0966c 0.78 -1.3
1,077,848 + -0.0
1,077,849 - -0.3
1,077,849 - -0.9
1,077,963 + +0.5
1,077,963 + +0.2
1,077,963 + +0.2
1,077,964 - +0.4
1,078,372 + +1.9
1,078,533 + Rv0968 0.48 +0.2
1,078,534 - Rv0968 0.48 -0.6
1,078,534 - Rv0968 0.48 -0.1
1,078,540 - Rv0968 0.50 +0.9
1,079,030 - Rv0969 0.12 -0.8
1,079,188 + Rv0969 0.19 -0.1

Or see this region's nucleotide sequence