Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0573c

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0572c and Rv0573c are separated by 467 nucleotidesRv0573c and Rv0574c are separated by 9 nucleotides Rv0572c: Rv0572c - Hypothetical protein, at 665,042 to 665,383 Rv0572c Rv0573c: Rv0573c - Nicotinic acid phosphoribosyltransferase PncB2, at 665,851 to 667,242 Rv0573c Rv0574c: Rv0574c - Conserved hypothetical protein, at 667,252 to 668,394 Rv0574c Position (kb) 665 666 667 668Strain fitness (log2 ratio) -1 0 1 2at 664.861 kb on - strandat 664.919 kb on + strandat 664.920 kb on - strandat 664.925 kb on - strandat 664.973 kb on + strandat 665.045 kb on + strandat 665.046 kb on - strandat 665.133 kb on + strand, within Rv0572cat 665.134 kb on - strand, within Rv0572cat 665.134 kb on - strand, within Rv0572cat 665.212 kb on - strand, within Rv0572cat 665.214 kb on + strand, within Rv0572cat 665.214 kb on + strand, within Rv0572cat 665.215 kb on - strand, within Rv0572cat 665.338 kb on + strand, within Rv0572cat 665.339 kb on - strand, within Rv0572cat 665.419 kb on + strandat 665.420 kb on - strandat 665.488 kb on - strandat 665.492 kb on - strandat 665.543 kb on + strandat 665.543 kb on + strandat 665.543 kb on + strandat 665.543 kb on + strandat 665.544 kb on - strandat 665.544 kb on - strandat 665.546 kb on - strandat 665.670 kb on + strandat 665.670 kb on + strandat 665.670 kb on + strandat 665.829 kb on + strandat 665.972 kb on + strandat 666.260 kb on + strand, within Rv0573cat 666.261 kb on - strand, within Rv0573cat 666.539 kb on - strand, within Rv0573cat 666.548 kb on + strand, within Rv0573cat 666.549 kb on - strand, within Rv0573cat 666.549 kb on - strand, within Rv0573cat 666.717 kb on - strand, within Rv0573cat 667.028 kb on + strand, within Rv0573cat 667.104 kb on - strandat 667.254 kb on - strandat 667.472 kb on + strand, within Rv0574cat 667.473 kb on - strand, within Rv0574cat 667.473 kb on - strand, within Rv0574cat 667.473 kb on - strand, within Rv0574cat 667.524 kb on - strand, within Rv0574cat 667.572 kb on - strand, within Rv0574cat 667.572 kb on - strand, within Rv0574cat 667.572 kb on - strand, within Rv0574cat 667.572 kb on - strand, within Rv0574cat 667.573 kb on + strand, within Rv0574cat 667.573 kb on + strand, within Rv0574cat 667.574 kb on - strand, within Rv0574cat 667.574 kb on - strand, within Rv0574cat 667.676 kb on + strand, within Rv0574cat 667.677 kb on - strand, within Rv0574cat 667.709 kb on - strand, within Rv0574cat 668.087 kb on + strand, within Rv0574c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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664,861 - +2.5
664,919 + +0.9
664,920 - -0.7
664,925 - +2.2
664,973 + -0.2
665,045 + +1.2
665,046 - +0.1
665,133 + Rv0572c 0.27 -0.7
665,134 - Rv0572c 0.27 +0.9
665,134 - Rv0572c 0.27 +0.7
665,212 - Rv0572c 0.50 -1.5
665,214 + Rv0572c 0.50 -1.1
665,214 + Rv0572c 0.50 +0.1
665,215 - Rv0572c 0.51 +0.6
665,338 + Rv0572c 0.87 +0.0
665,339 - Rv0572c 0.87 +0.2
665,419 + -0.7
665,420 - -1.2
665,488 - -0.6
665,492 - -0.8
665,543 + -0.1
665,543 + -0.2
665,543 + +0.5
665,543 + +0.2
665,544 - +0.3
665,544 - +0.1
665,546 - +0.4
665,670 + +0.0
665,670 + +0.0
665,670 + +0.1
665,829 + +0.0
665,972 + -0.1
666,260 + Rv0573c 0.29 -0.7
666,261 - Rv0573c 0.29 -1.1
666,539 - Rv0573c 0.49 -0.6
666,548 + Rv0573c 0.50 -1.0
666,549 - Rv0573c 0.50 -0.6
666,549 - Rv0573c 0.50 -0.4
666,717 - Rv0573c 0.62 -0.8
667,028 + Rv0573c 0.85 -1.4
667,104 - -1.4
667,254 - +0.1
667,472 + Rv0574c 0.19 -0.2
667,473 - Rv0574c 0.19 +0.1
667,473 - Rv0574c 0.19 -1.1
667,473 - Rv0574c 0.19 +0.9
667,524 - Rv0574c 0.24 +0.9
667,572 - Rv0574c 0.28 -0.2
667,572 - Rv0574c 0.28 +0.7
667,572 - Rv0574c 0.28 -0.2
667,572 - Rv0574c 0.28 -0.9
667,573 + Rv0574c 0.28 +0.5
667,573 + Rv0574c 0.28 -1.1
667,574 - Rv0574c 0.28 +0.1
667,574 - Rv0574c 0.28 +1.1
667,676 + Rv0574c 0.37 +0.4
667,677 - Rv0574c 0.37 +1.0
667,709 - Rv0574c 0.40 +0.5
668,087 + Rv0574c 0.73 -0.2

Or see this region's nucleotide sequence