Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0409

Experiment: 7H9 with Delamanid 0.236 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0408 and Rv0409 overlap by 8 nucleotidesRv0409 and Rv0410c are separated by 53 nucleotides Rv0408: Rv0408 - Probable phosphate acetyltransferase Pta (phosphotransacetylase), at 491,786 to 493,858 Rv0408 Rv0409: Rv0409 - Probable acetate kinase AckA (acetokinase), at 493,851 to 495,008 Rv0409 Rv0410c: Rv0410c - Serine/threonine-protein kinase PknG (protein kinase G) (STPK G), at 495,062 to 497,314 Rv0410c Position (kb) 493 494 495 496Strain fitness (log2 ratio) -2 -1 0 1at 492.869 kb on - strand, within Rv0408at 492.888 kb on - strand, within Rv0408at 493.356 kb on + strand, within Rv0408at 493.357 kb on - strand, within Rv0408at 493.364 kb on + strand, within Rv0408at 493.700 kb on + strandat 493.806 kb on + strandat 493.807 kb on - strandat 494.287 kb on - strand, within Rv0409at 494.358 kb on + strand, within Rv0409at 494.359 kb on - strand, within Rv0409at 494.359 kb on - strand, within Rv0409at 494.557 kb on - strand, within Rv0409at 494.666 kb on - strand, within Rv0409at 494.745 kb on + strand, within Rv0409at 494.852 kb on + strand, within Rv0409at 495.064 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Delamanid 0.236 ug/mL
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492,869 - Rv0408 0.52 +0.5
492,888 - Rv0408 0.53 -0.7
493,356 + Rv0408 0.76 +0.0
493,357 - Rv0408 0.76 -2.7
493,364 + Rv0408 0.76 -0.6
493,700 + +0.1
493,806 + +0.1
493,807 - +0.4
494,287 - Rv0409 0.38 +0.4
494,358 + Rv0409 0.44 +1.1
494,359 - Rv0409 0.44 -0.4
494,359 - Rv0409 0.44 +0.1
494,557 - Rv0409 0.61 -0.2
494,666 - Rv0409 0.70 -0.1
494,745 + Rv0409 0.77 +0.9
494,852 + Rv0409 0.86 -0.3
495,064 - +0.0

Or see this region's nucleotide sequence