Experiment: Lomefloxacin 0.000390625 mM
Only strains with sufficient reads to estimate fitness are shown,
but the strain fitness values are still rather noisy and may be biased towards zero.
Strains near the edge of a gene are not shown as being associated with that
gene (they are in grey).
Strains in the central 10-90% of a gene are color coded by the insertion's strand.
Usually, "+" means that the selectable marker is encoded on the forward strand,
i.e., transcribed rightward.
500 nt Sama_0243 and Sama_0244 are separated by 1 nucleotides Sama_0244 and Sama_0245 are separated by 11 nucleotides Sama_0245 and Sama_0246 are separated by 310 nucleotides Sama_0246 and Sama_0247 are separated by 148 nucleotides
Sama_0243: Sama_0243 - heme exporter protein CcmC (RefSeq), at 267,296 to 268,042
_0243
Sama_0244: Sama_0244 - heme exporter protein CcmB (RefSeq), at 268,044 to 268,730
_0244
Sama_0245: Sama_0245 - cytochrome c biogenesis protein CcmA (RefSeq), at 268,742 to 269,395
_0245
Sama_0246: Sama_0246 - cytochrome c (RefSeq), at 269,706 to 269,999
_0246
Sama_0247: Sama_0247 - cytochrome c-type biogenesis protein CcmH (RefSeq), at 270,148 to 271,401
_0247
Position (kb) 268
269
270 Strain fitness (log2 ratio) -4
-3
-2
-1
0
1 at 267.784 kb on + strand, within Sama_0243 at 267.805 kb on + strand, within Sama_0243 at 267.806 kb on - strand, within Sama_0243 at 267.829 kb on + strand, within Sama_0243 at 267.829 kb on + strand, within Sama_0243 at 267.830 kb on - strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.831 kb on + strand, within Sama_0243 at 267.832 kb on - strand, within Sama_0243 at 267.832 kb on - strand, within Sama_0243 at 267.868 kb on + strand, within Sama_0243 at 267.900 kb on + strand, within Sama_0243 at 267.901 kb on - strand, within Sama_0243 at 267.901 kb on - strand, within Sama_0243 at 267.901 kb on - strand, within Sama_0243 at 267.946 kb on + strand, within Sama_0243 at 267.978 kb on - strand at 267.978 kb on - strand at 267.992 kb on + strand at 268.000 kb on - strand at 268.028 kb on + strand at 268.029 kb on - strand at 268.043 kb on - strand at 268.045 kb on + strand at 268.045 kb on + strand at 268.046 kb on - strand at 268.046 kb on - strand at 268.049 kb on + strand at 268.050 kb on - strand at 268.050 kb on - strand at 268.119 kb on + strand, within Sama_0244 at 268.119 kb on + strand, within Sama_0244 at 268.120 kb on - strand, within Sama_0244 at 268.120 kb on - strand, within Sama_0244 at 268.120 kb on - strand, within Sama_0244 at 268.122 kb on + strand, within Sama_0244 at 268.142 kb on - strand, within Sama_0244 at 268.142 kb on - strand, within Sama_0244 at 268.147 kb on - strand, within Sama_0244 at 268.201 kb on + strand, within Sama_0244 at 268.202 kb on - strand, within Sama_0244 at 268.202 kb on - strand, within Sama_0244 at 268.202 kb on - strand, within Sama_0244 at 268.212 kb on + strand, within Sama_0244 at 268.213 kb on - strand, within Sama_0244 at 268.215 kb on - strand, within Sama_0244 at 268.216 kb on - strand, within Sama_0244 at 268.231 kb on - strand, within Sama_0244 at 268.241 kb on + strand, within Sama_0244 at 268.242 kb on - strand, within Sama_0244 at 268.242 kb on - strand, within Sama_0244 at 268.245 kb on + strand, within Sama_0244 at 268.245 kb on + strand, within Sama_0244 at 268.245 kb on + strand, within Sama_0244 at 268.246 kb on - strand, within Sama_0244 at 268.246 kb on - strand, within Sama_0244 at 268.269 kb on + strand, within Sama_0244 at 268.269 kb on + strand, within Sama_0244 at 268.270 kb on - strand, within Sama_0244 at 268.270 kb on - strand, within Sama_0244 at 268.270 kb on - strand, within Sama_0244 at 268.270 kb on - strand, within Sama_0244 at 268.270 kb on - strand, within Sama_0244 at 268.298 kb on + strand, within Sama_0244 at 268.330 kb on + strand, within Sama_0244 at 268.330 kb on + strand, within Sama_0244 at 268.331 kb on - strand, within Sama_0244 at 268.331 kb on - strand, within Sama_0244 at 268.331 kb on - strand, within Sama_0244 at 268.439 kb on - strand, within Sama_0244 at 268.439 kb on - strand, within Sama_0244 at 268.456 kb on - strand, within Sama_0244 at 268.539 kb on + strand, within Sama_0244 at 268.573 kb on - strand, within Sama_0244 at 268.573 kb on - strand, within Sama_0244 at 268.689 kb on + strand at 268.689 kb on + strand at 268.690 kb on - strand at 268.709 kb on + strand at 268.715 kb on + strand at 268.716 kb on - strand at 268.716 kb on - strand at 268.716 kb on - strand at 268.744 kb on - strand at 268.744 kb on - strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.745 kb on + strand at 268.746 kb on - strand at 268.746 kb on - strand at 268.746 kb on - strand at 268.746 kb on - strand at 268.746 kb on - strand at 268.746 kb on - strand at 268.755 kb on + strand at 268.756 kb on - strand at 268.897 kb on + strand, within Sama_0245 at 268.980 kb on - strand, within Sama_0245 at 269.055 kb on + strand, within Sama_0245 at 269.070 kb on - strand, within Sama_0245 at 269.081 kb on - strand, within Sama_0245 at 269.133 kb on + strand, within Sama_0245 at 269.133 kb on + strand, within Sama_0245 at 269.134 kb on - strand, within Sama_0245 at 269.138 kb on + strand, within Sama_0245 at 269.138 kb on + strand, within Sama_0245 at 269.139 kb on - strand, within Sama_0245 at 269.139 kb on - strand, within Sama_0245 at 269.139 kb on - strand, within Sama_0245 at 269.139 kb on - strand, within Sama_0245 at 269.282 kb on - strand, within Sama_0245 at 269.361 kb on - strand at 269.387 kb on + strand at 269.388 kb on - strand at 269.405 kb on + strand at 269.405 kb on + strand at 269.406 kb on - strand at 269.406 kb on - strand at 269.406 kb on - strand at 269.406 kb on - strand at 269.416 kb on - strand at 269.430 kb on - strand at 269.432 kb on + strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.433 kb on - strand at 269.437 kb on + strand at 269.437 kb on + strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.438 kb on - strand at 269.456 kb on - strand at 269.466 kb on + strand at 269.466 kb on + strand at 269.466 kb on + strand at 269.467 kb on - strand at 269.467 kb on - strand at 269.467 kb on - strand at 269.471 kb on + strand at 269.471 kb on + strand at 269.471 kb on + strand at 269.472 kb on - strand at 269.472 kb on - strand at 269.472 kb on - strand at 269.472 kb on - strand at 269.475 kb on + strand at 269.475 kb on + strand at 269.476 kb on - strand at 269.476 kb on - strand at 269.500 kb on + strand at 269.501 kb on - strand at 269.501 kb on - strand at 269.501 kb on - strand at 269.529 kb on + strand at 269.539 kb on + strand at 269.540 kb on - strand at 269.541 kb on + strand at 269.542 kb on - strand at 269.542 kb on - strand at 269.542 kb on - strand at 269.560 kb on + strand at 269.560 kb on + strand at 269.625 kb on + strand at 269.625 kb on + strand at 269.625 kb on + strand at 269.626 kb on - strand at 269.626 kb on - strand at 269.633 kb on + strand at 269.642 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.679 kb on + strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.680 kb on - strand at 269.683 kb on + strand at 269.683 kb on + strand at 269.684 kb on - strand at 269.684 kb on - strand at 269.693 kb on - strand at 269.720 kb on - strand at 269.720 kb on - strand at 269.734 kb on + strand at 269.734 kb on + strand at 269.734 kb on + strand at 269.734 kb on + strand at 269.735 kb on - strand at 269.735 kb on - strand at 269.735 kb on - strand at 269.735 kb on - strand at 269.747 kb on + strand, within Sama_0246 at 269.747 kb on + strand, within Sama_0246 at 269.762 kb on - strand, within Sama_0246 at 269.785 kb on + strand, within Sama_0246 at 269.785 kb on + strand, within Sama_0246 at 269.785 kb on + strand, within Sama_0246 at 269.786 kb on - strand, within Sama_0246 at 269.786 kb on - strand, within Sama_0246 at 269.786 kb on - strand, within Sama_0246 at 269.786 kb on - strand, within Sama_0246 at 269.786 kb on - strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.787 kb on + strand, within Sama_0246 at 269.788 kb on - strand, within Sama_0246 at 269.788 kb on - strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.789 kb on + strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.790 kb on - strand, within Sama_0246 at 269.806 kb on + strand, within Sama_0246 at 269.806 kb on + strand, within Sama_0246 at 269.807 kb on - strand, within Sama_0246 at 269.807 kb on - strand, within Sama_0246 at 269.807 kb on - strand, within Sama_0246 at 269.807 kb on - strand, within Sama_0246 at 269.807 kb on - strand, within Sama_0246 at 269.824 kb on + strand, within Sama_0246 at 269.882 kb on + strand, within Sama_0246 at 269.882 kb on + strand, within Sama_0246 at 269.955 kb on - strand, within Sama_0246 at 270.008 kb on + strand at 270.008 kb on + strand at 270.008 kb on + strand at 270.008 kb on + strand at 270.009 kb on - strand at 270.009 kb on - strand at 270.042 kb on - strand at 270.118 kb on + strand at 270.118 kb on + strand at 270.123 kb on + strand at 270.124 kb on - strand at 270.131 kb on + strand at 270.131 kb on + strand at 270.131 kb on + strand at 270.132 kb on - strand at 270.149 kb on + strand at 270.150 kb on - strand at 270.170 kb on - strand at 270.170 kb on - strand at 270.207 kb on + strand at 270.207 kb on + strand at 270.207 kb on + strand at 270.208 kb on - strand at 270.208 kb on - strand at 270.219 kb on + strand at 270.220 kb on - strand at 270.220 kb on - strand at 270.220 kb on + strand at 270.241 kb on - strand at 270.315 kb on + strand, within Sama_0247 at 270.316 kb on - strand, within Sama_0247 at 270.316 kb on - strand, within Sama_0247 at 270.324 kb on + strand, within Sama_0247 at 270.324 kb on + strand, within Sama_0247 at 270.325 kb on - strand, within Sama_0247 at 270.325 kb on - strand, within Sama_0247 at 270.325 kb on - strand, within Sama_0247 at 270.339 kb on + strand, within Sama_0247 at 270.340 kb on - strand, within Sama_0247 at 270.340 kb on - strand, within Sama_0247 at 270.340 kb on - strand, within Sama_0247
Per-strain Table
Position Strand Gene LocusTag Fraction Lomefloxacin 0.000390625 mM remove 267,784 + Sama_0243 0.65 -1.5 267,805 + Sama_0243 0.68 -1.9 267,806 - Sama_0243 0.68 -2.3 267,829 + Sama_0243 0.71 -1.7 267,829 + Sama_0243 0.71 +0.1 267,830 - Sama_0243 0.71 +0.3 267,831 + Sama_0243 0.72 -0.5 267,831 + Sama_0243 0.72 -0.9 267,831 + Sama_0243 0.72 -1.3 267,831 + Sama_0243 0.72 -1.3 267,831 + Sama_0243 0.72 -1.7 267,831 + Sama_0243 0.72 +0.1 267,831 + Sama_0243 0.72 -1.3 267,832 - Sama_0243 0.72 -1.3 267,832 - Sama_0243 0.72 -1.3 267,868 + Sama_0243 0.77 -1.7 267,900 + Sama_0243 0.81 -0.7 267,901 - Sama_0243 0.81 -1.3 267,901 - Sama_0243 0.81 -2.9 267,901 - Sama_0243 0.81 -1.3 267,946 + Sama_0243 0.87 -2.1 267,978 - -1.3 267,978 - -1.9 267,992 + -0.7 268,000 - -2.7 268,028 + -0.9 268,029 - -1.2 268,043 - -1.9 268,045 + -1.2 268,045 + -2.8 268,046 - -1.7 268,046 - -2.9 268,049 + -0.9 268,050 - -2.4 268,050 - -2.1 268,119 + Sama_0244 0.11 -0.7 268,119 + Sama_0244 0.11 -1.9 268,120 - Sama_0244 0.11 -0.1 268,120 - Sama_0244 0.11 -1.9 268,120 - Sama_0244 0.11 -1.7 268,122 + Sama_0244 0.11 -0.9 268,142 - Sama_0244 0.14 -1.5 268,142 - Sama_0244 0.14 +1.1 268,147 - Sama_0244 0.15 -0.5 268,201 + Sama_0244 0.23 -1.9 268,202 - Sama_0244 0.23 -1.7 268,202 - Sama_0244 0.23 -2.2 268,202 - Sama_0244 0.23 -0.8 268,212 + Sama_0244 0.24 -1.9 268,213 - Sama_0244 0.25 -0.2 268,215 - Sama_0244 0.25 -1.5 268,216 - Sama_0244 0.25 -1.7 268,231 - Sama_0244 0.27 -1.5 268,241 + Sama_0244 0.29 -1.7 268,242 - Sama_0244 0.29 -0.9 268,242 - Sama_0244 0.29 -1.7 268,245 + Sama_0244 0.29 -0.9 268,245 + Sama_0244 0.29 -0.3 268,245 + Sama_0244 0.29 -0.5 268,246 - Sama_0244 0.29 -0.5 268,246 - Sama_0244 0.29 -0.5 268,269 + Sama_0244 0.33 -0.5 268,269 + Sama_0244 0.33 -0.9 268,270 - Sama_0244 0.33 -1.2 268,270 - Sama_0244 0.33 -1.5 268,270 - Sama_0244 0.33 -0.9 268,270 - Sama_0244 0.33 -1.9 268,270 - Sama_0244 0.33 -3.2 268,298 + Sama_0244 0.37 -0.9 268,330 + Sama_0244 0.42 -1.7 268,330 + Sama_0244 0.42 -2.6 268,331 - Sama_0244 0.42 -1.9 268,331 - Sama_0244 0.42 -2.7 268,331 - Sama_0244 0.42 -1.2 268,439 - Sama_0244 0.57 -2.4 268,439 - Sama_0244 0.57 -0.9 268,456 - Sama_0244 0.60 -1.2 268,539 + Sama_0244 0.72 -1.7 268,573 - Sama_0244 0.77 -2.0 268,573 - Sama_0244 0.77 -2.5 268,689 + -0.9 268,689 + -2.4 268,690 - -0.9 268,709 + -2.4 268,715 + -1.9 268,716 - -0.5 268,716 - -2.1 268,716 - -1.5 268,744 - -2.4 268,744 - -1.2 268,745 + -3.4 268,745 + -2.9 268,745 + -2.5 268,745 + +0.1 268,745 + -0.9 268,745 + -0.2 268,745 + -2.2 268,746 - -2.4 268,746 - -1.7 268,746 - -1.9 268,746 - -1.5 268,746 - -2.4 268,746 - -2.2 268,755 + -1.2 268,756 - -1.2 268,897 + Sama_0245 0.24 -1.5 268,980 - Sama_0245 0.36 -1.2 269,055 + Sama_0245 0.48 -1.8 269,070 - Sama_0245 0.50 -1.5 269,081 - Sama_0245 0.52 -1.9 269,133 + Sama_0245 0.60 -1.9 269,133 + Sama_0245 0.60 -1.7 269,134 - Sama_0245 0.60 -2.2 269,138 + Sama_0245 0.61 -1.2 269,138 + Sama_0245 0.61 -2.5 269,139 - Sama_0245 0.61 -0.9 269,139 - Sama_0245 0.61 -1.9 269,139 - Sama_0245 0.61 -2.4 269,139 - Sama_0245 0.61 -2.1 269,282 - Sama_0245 0.83 -1.9 269,361 - -0.4 269,387 + -2.5 269,388 - -1.5 269,405 + -0.7 269,405 + -1.2 269,406 - -1.4 269,406 - -0.0 269,406 - -0.6 269,406 - +1.1 269,416 - -0.7 269,430 - +0.3 269,432 + -2.0 269,433 - -0.3 269,433 - -1.2 269,433 - -1.6 269,433 - -1.6 269,433 - -1.5 269,433 - -0.8 269,433 - +0.2 269,437 + -0.5 269,437 + +1.4 269,438 - -1.1 269,438 - -2.5 269,438 - +0.2 269,438 - -0.1 269,438 - -0.2 269,438 - -2.8 269,438 - -1.5 269,438 - -0.1 269,456 - -0.6 269,466 + -0.6 269,466 + -1.0 269,466 + -0.0 269,467 - -0.4 269,467 - -2.1 269,467 - +0.0 269,471 + -0.5 269,471 + -2.9 269,471 + -0.7 269,472 - -1.1 269,472 - -0.9 269,472 - +0.3 269,472 - -0.1 269,475 + -0.2 269,475 + -0.2 269,476 - +0.2 269,476 - -0.9 269,500 + -1.4 269,501 - -1.7 269,501 - -0.1 269,501 - -0.7 269,529 + +0.1 269,539 + -0.7 269,540 - -0.2 269,541 + -2.2 269,542 - -1.1 269,542 - -1.4 269,542 - -0.6 269,560 + -0.4 269,560 + +0.3 269,625 + -0.2 269,625 + -2.2 269,625 + -1.0 269,626 - -1.3 269,626 - +0.3 269,633 + -1.2 269,642 + -1.6 269,679 + +0.6 269,679 + -0.5 269,679 + -0.9 269,679 + -1.3 269,679 + +0.4 269,679 + +0.3 269,679 + -1.2 269,679 + -1.2 269,679 + +0.9 269,679 + -1.1 269,679 + -0.7 269,679 + -0.7 269,680 - -2.4 269,680 - -1.7 269,680 - -1.7 269,680 - -1.2 269,680 - -1.1 269,680 - -1.9 269,680 - -2.4 269,680 - -0.9 269,680 - -1.7 269,683 + -2.6 269,683 + -0.7 269,684 - -1.2 269,684 - -2.5 269,693 - -1.2 269,720 - -2.9 269,720 - -2.5 269,734 + -3.6 269,734 + +0.1 269,734 + -1.1 269,734 + -1.5 269,735 - -1.1 269,735 - -0.9 269,735 - -1.2 269,735 - -1.1 269,747 + Sama_0246 0.14 -1.7 269,747 + Sama_0246 0.14 -3.9 269,762 - Sama_0246 0.19 -1.9 269,785 + Sama_0246 0.27 +0.3 269,785 + Sama_0246 0.27 -2.2 269,785 + Sama_0246 0.27 -2.0 269,786 - Sama_0246 0.27 -2.4 269,786 - Sama_0246 0.27 -3.9 269,786 - Sama_0246 0.27 -0.2 269,786 - Sama_0246 0.27 -1.9 269,786 - Sama_0246 0.27 -1.4 269,787 + Sama_0246 0.28 -0.9 269,787 + Sama_0246 0.28 -1.4 269,787 + Sama_0246 0.28 -3.2 269,787 + Sama_0246 0.28 -1.6 269,787 + Sama_0246 0.28 -1.7 269,787 + Sama_0246 0.28 -3.0 269,788 - Sama_0246 0.28 -2.6 269,788 - Sama_0246 0.28 -0.5 269,789 + Sama_0246 0.28 -1.7 269,789 + Sama_0246 0.28 -2.2 269,789 + Sama_0246 0.28 -2.1 269,789 + Sama_0246 0.28 -1.6 269,789 + Sama_0246 0.28 -2.6 269,789 + Sama_0246 0.28 -0.9 269,789 + Sama_0246 0.28 -2.7 269,789 + Sama_0246 0.28 -0.9 269,789 + Sama_0246 0.28 -1.7 269,789 + Sama_0246 0.28 -0.9 269,790 - Sama_0246 0.29 -0.5 269,790 - Sama_0246 0.29 +0.1 269,790 - Sama_0246 0.29 -2.1 269,790 - Sama_0246 0.29 -1.7 269,790 - Sama_0246 0.29 -1.2 269,790 - Sama_0246 0.29 -3.1 269,806 + Sama_0246 0.34 -1.4 269,806 + Sama_0246 0.34 -0.5 269,807 - Sama_0246 0.34 -1.7 269,807 - Sama_0246 0.34 -1.5 269,807 - Sama_0246 0.34 -1.5 269,807 - Sama_0246 0.34 -0.2 269,807 - Sama_0246 0.34 -2.1 269,824 + Sama_0246 0.40 -2.2 269,882 + Sama_0246 0.60 -1.9 269,882 + Sama_0246 0.60 -1.9 269,955 - Sama_0246 0.85 -3.6 270,008 + -1.9 270,008 + -2.5 270,008 + -1.1 270,008 + -2.8 270,009 - +0.4 270,009 - -0.7 270,042 - -1.4 270,118 + -1.3 270,118 + -0.7 270,123 + -2.2 270,124 - -1.3 270,131 + -0.6 270,131 + -1.4 270,131 + +0.4 270,132 - -1.1 270,149 + -0.1 270,150 - -0.8 270,170 - -0.6 270,170 - +0.1 270,207 + -1.7 270,207 + -1.1 270,207 + -0.2 270,208 - -0.2 270,208 - +0.3 270,219 + -2.9 270,220 - -0.9 270,220 - -0.9 270,220 + -0.3 270,241 - -0.8 270,315 + Sama_0247 0.13 -1.2 270,316 - Sama_0247 0.13 -1.3 270,316 - Sama_0247 0.13 -0.5 270,324 + Sama_0247 0.14 -1.2 270,324 + Sama_0247 0.14 -1.2 270,325 - Sama_0247 0.14 -0.3 270,325 - Sama_0247 0.14 -0.7 270,325 - Sama_0247 0.14 -0.2 270,339 + Sama_0247 0.15 -1.1 270,340 - Sama_0247 0.15 -0.9 270,340 - Sama_0247 0.15 +0.4 270,340 - Sama_0247 0.15 +0.5
Or see this region's nucleotide sequence