Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3616c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3614c and Rv3615c are separated by 115 nucleotidesRv3615c and Rv3616c are separated by 73 nucleotides Rv3614c: Rv3614c - ESX-1 secretion-associated protein EspD, at 4,054,142 to 4,054,696 Rv3614c Rv3615c: Rv3615c - ESX-1 secretion-associated protein EspC, at 4,054,812 to 4,055,123 Rv3615c Rv3616c: Rv3616c - ESX-1 secretion-associated protein A, EspA, at 4,055,197 to 4,056,375 Rv3616c Position (kb) 4055 4056 4057Strain fitness (log2 ratio) -2 -1 0 1 2 3at 4054.241 kb on + strand, within Rv3614cat 4054.267 kb on + strand, within Rv3614cat 4054.267 kb on + strand, within Rv3614cat 4054.268 kb on - strand, within Rv3614cat 4054.271 kb on + strand, within Rv3614cat 4054.272 kb on - strand, within Rv3614cat 4054.272 kb on - strand, within Rv3614cat 4054.335 kb on + strand, within Rv3614cat 4054.600 kb on + strand, within Rv3614cat 4054.818 kb on - strandat 4054.818 kb on - strandat 4054.862 kb on + strand, within Rv3615cat 4054.863 kb on - strand, within Rv3615cat 4054.865 kb on - strand, within Rv3615cat 4054.866 kb on + strand, within Rv3615cat 4054.866 kb on + strand, within Rv3615cat 4054.867 kb on - strand, within Rv3615cat 4054.867 kb on - strand, within Rv3615cat 4054.951 kb on + strand, within Rv3615cat 4054.951 kb on + strand, within Rv3615cat 4054.951 kb on + strand, within Rv3615cat 4054.959 kb on + strand, within Rv3615cat 4054.960 kb on - strand, within Rv3615cat 4054.960 kb on - strand, within Rv3615cat 4054.960 kb on - strand, within Rv3615cat 4055.082 kb on + strand, within Rv3615cat 4055.083 kb on - strand, within Rv3615cat 4055.083 kb on - strand, within Rv3615cat 4055.143 kb on + strandat 4055.144 kb on - strandat 4055.297 kb on + strandat 4055.371 kb on - strand, within Rv3616cat 4055.924 kb on + strand, within Rv3616cat 4055.925 kb on - strand, within Rv3616cat 4055.944 kb on + strand, within Rv3616cat 4055.944 kb on + strand, within Rv3616cat 4055.945 kb on - strand, within Rv3616cat 4055.945 kb on - strand, within Rv3616cat 4055.945 kb on - strand, within Rv3616cat 4055.945 kb on - strand, within Rv3616cat 4056.014 kb on + strand, within Rv3616cat 4056.014 kb on + strand, within Rv3616cat 4056.015 kb on - strand, within Rv3616cat 4056.015 kb on - strand, within Rv3616cat 4056.189 kb on - strand, within Rv3616cat 4056.189 kb on - strand, within Rv3616cat 4056.209 kb on - strand, within Rv3616cat 4056.264 kb on - strandat 4056.268 kb on + strandat 4056.269 kb on - strandat 4056.269 kb on - strandat 4056.323 kb on + strandat 4056.324 kb on - strandat 4056.324 kb on - strandat 4056.386 kb on + strandat 4056.413 kb on + strandat 4056.413 kb on + strandat 4056.446 kb on - strandat 4056.610 kb on + strandat 4056.672 kb on + strandat 4056.696 kb on + strandat 4056.697 kb on - strandat 4056.698 kb on + strandat 4056.698 kb on + strandat 4056.700 kb on + strandat 4056.701 kb on - strandat 4056.701 kb on - strandat 4056.701 kb on - strandat 4056.701 kb on - strandat 4057.052 kb on + strandat 4057.198 kb on + strandat 4057.198 kb on + strandat 4057.253 kb on + strandat 4057.253 kb on + strandat 4057.254 kb on - strandat 4057.275 kb on + strandat 4057.275 kb on + strandat 4057.275 kb on + strandat 4057.320 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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4,054,241 + Rv3614c 0.18 -0.6
4,054,267 + Rv3614c 0.23 -0.9
4,054,267 + Rv3614c 0.23 -0.1
4,054,268 - Rv3614c 0.23 +0.9
4,054,271 + Rv3614c 0.23 -0.7
4,054,272 - Rv3614c 0.23 +0.2
4,054,272 - Rv3614c 0.23 -1.3
4,054,335 + Rv3614c 0.35 -0.0
4,054,600 + Rv3614c 0.83 +0.9
4,054,818 - -0.1
4,054,818 - +1.2
4,054,862 + Rv3615c 0.16 -0.2
4,054,863 - Rv3615c 0.16 -0.4
4,054,865 - Rv3615c 0.17 -0.1
4,054,866 + Rv3615c 0.17 +0.9
4,054,866 + Rv3615c 0.17 +0.0
4,054,867 - Rv3615c 0.18 -2.6
4,054,867 - Rv3615c 0.18 +0.9
4,054,951 + Rv3615c 0.45 +0.5
4,054,951 + Rv3615c 0.45 +1.5
4,054,951 + Rv3615c 0.45 +0.1
4,054,959 + Rv3615c 0.47 -0.6
4,054,960 - Rv3615c 0.47 -0.1
4,054,960 - Rv3615c 0.47 -0.0
4,054,960 - Rv3615c 0.47 -0.7
4,055,082 + Rv3615c 0.87 -0.4
4,055,083 - Rv3615c 0.87 +0.2
4,055,083 - Rv3615c 0.87 +0.2
4,055,143 + -0.7
4,055,144 - -0.3
4,055,297 + +0.1
4,055,371 - Rv3616c 0.15 +0.6
4,055,924 + Rv3616c 0.62 +0.1
4,055,925 - Rv3616c 0.62 +0.2
4,055,944 + Rv3616c 0.63 -0.7
4,055,944 + Rv3616c 0.63 -0.2
4,055,945 - Rv3616c 0.63 +0.0
4,055,945 - Rv3616c 0.63 +0.6
4,055,945 - Rv3616c 0.63 -0.4
4,055,945 - Rv3616c 0.63 +0.4
4,056,014 + Rv3616c 0.69 +1.0
4,056,014 + Rv3616c 0.69 -0.1
4,056,015 - Rv3616c 0.69 +0.9
4,056,015 - Rv3616c 0.69 +0.2
4,056,189 - Rv3616c 0.84 +0.7
4,056,189 - Rv3616c 0.84 +1.0
4,056,209 - Rv3616c 0.86 -0.3
4,056,264 - +1.5
4,056,268 + +0.3
4,056,269 - +0.0
4,056,269 - +0.5
4,056,323 + +0.1
4,056,324 - +0.2
4,056,324 - +0.3
4,056,386 + +0.4
4,056,413 + -0.1
4,056,413 + +3.5
4,056,446 - +0.3
4,056,610 + -0.1
4,056,672 + +0.7
4,056,696 + -0.2
4,056,697 - -0.4
4,056,698 + +0.9
4,056,698 + -0.1
4,056,700 + -0.3
4,056,701 - -1.9
4,056,701 - +0.4
4,056,701 - +3.7
4,056,701 - +0.2
4,057,052 + +0.4
4,057,198 + +0.4
4,057,198 + +0.2
4,057,253 + +0.1
4,057,253 + +0.0
4,057,254 - -0.7
4,057,275 + +0.9
4,057,275 + +0.7
4,057,275 + +0.3
4,057,320 + +1.2

Or see this region's nucleotide sequence