Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3433c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3432c and Rv3433c are separated by 37 nucleotidesRv3433c and Rv3434c are separated by 1 nucleotidesRv3434c and Rv3435c are separated by 10 nucleotides Rv3432c: Rv3432c - Probable glutamate decarboxylase GadB, at 3,850,372 to 3,851,754 Rv3432c Rv3433c: Rv3433c - Conserved protein, at 3,851,792 to 3,853,213 Rv3433c Rv3434c: Rv3434c - Possible conserved transmembrane protein, at 3,853,215 to 3,853,928 Rv3434c Rv3435c: Rv3435c - Probable conserved transmembrane protein, at 3,853,939 to 3,854,793 Rv3435c Position (kb) 3851 3852 3853 3854Strain fitness (log2 ratio) -2 -1 0 1 2at 3850.839 kb on - strand, within Rv3432cat 3850.910 kb on + strand, within Rv3432cat 3850.922 kb on + strand, within Rv3432cat 3851.032 kb on + strand, within Rv3432cat 3851.032 kb on + strand, within Rv3432cat 3851.033 kb on - strand, within Rv3432cat 3851.112 kb on + strand, within Rv3432cat 3851.113 kb on - strand, within Rv3432cat 3851.114 kb on + strand, within Rv3432cat 3851.114 kb on + strand, within Rv3432cat 3851.114 kb on + strand, within Rv3432cat 3851.115 kb on - strand, within Rv3432cat 3851.115 kb on - strand, within Rv3432cat 3851.115 kb on - strand, within Rv3432cat 3851.193 kb on - strand, within Rv3432cat 3851.499 kb on + strand, within Rv3432cat 3851.595 kb on + strand, within Rv3432cat 3851.595 kb on + strand, within Rv3432cat 3851.630 kb on + strandat 3851.706 kb on - strandat 3851.706 kb on - strandat 3851.793 kb on + strandat 3851.793 kb on + strandat 3851.794 kb on - strandat 3851.794 kb on - strandat 3852.027 kb on + strand, within Rv3433cat 3852.531 kb on + strand, within Rv3433cat 3852.532 kb on - strand, within Rv3433cat 3852.532 kb on - strand, within Rv3433cat 3852.581 kb on - strand, within Rv3433cat 3853.200 kb on + strandat 3853.200 kb on + strandat 3853.201 kb on - strandat 3853.201 kb on - strandat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.454 kb on - strand, within Rv3434cat 3853.487 kb on - strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.573 kb on + strand, within Rv3434cat 3853.574 kb on - strand, within Rv3434cat 3853.847 kb on - strand, within Rv3434cat 3853.940 kb on + strandat 3853.941 kb on - strandat 3853.941 kb on - strandat 3853.941 kb on - strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.991 kb on + strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3853.992 kb on - strandat 3854.032 kb on + strand, within Rv3435cat 3854.120 kb on + strand, within Rv3435cat 3854.121 kb on - strand, within Rv3435c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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3,850,839 - Rv3432c 0.34 -0.4
3,850,910 + Rv3432c 0.39 -0.0
3,850,922 + Rv3432c 0.40 +0.1
3,851,032 + Rv3432c 0.48 -0.0
3,851,032 + Rv3432c 0.48 +1.0
3,851,033 - Rv3432c 0.48 +0.8
3,851,112 + Rv3432c 0.54 -0.6
3,851,113 - Rv3432c 0.54 +0.9
3,851,114 + Rv3432c 0.54 -0.6
3,851,114 + Rv3432c 0.54 -0.3
3,851,114 + Rv3432c 0.54 +0.5
3,851,115 - Rv3432c 0.54 +1.9
3,851,115 - Rv3432c 0.54 +0.0
3,851,115 - Rv3432c 0.54 -0.4
3,851,193 - Rv3432c 0.59 -0.9
3,851,499 + Rv3432c 0.81 -0.4
3,851,595 + Rv3432c 0.88 +0.9
3,851,595 + Rv3432c 0.88 -0.5
3,851,630 + -0.8
3,851,706 - +0.6
3,851,706 - -0.4
3,851,793 + +0.4
3,851,793 + -1.6
3,851,794 - -0.4
3,851,794 - +0.3
3,852,027 + Rv3433c 0.17 -1.1
3,852,531 + Rv3433c 0.52 -0.7
3,852,532 - Rv3433c 0.52 -1.1
3,852,532 - Rv3433c 0.52 -1.5
3,852,581 - Rv3433c 0.55 -0.7
3,853,200 + +0.3
3,853,200 + -0.4
3,853,201 - -0.5
3,853,201 - -0.4
3,853,454 - Rv3434c 0.33 -1.9
3,853,454 - Rv3434c 0.33 -1.5
3,853,454 - Rv3434c 0.33 -0.7
3,853,454 - Rv3434c 0.33 -1.7
3,853,454 - Rv3434c 0.33 -0.4
3,853,487 - Rv3434c 0.38 -0.0
3,853,573 + Rv3434c 0.50 -0.1
3,853,573 + Rv3434c 0.50 +0.5
3,853,573 + Rv3434c 0.50 -0.7
3,853,574 - Rv3434c 0.50 -0.1
3,853,847 - Rv3434c 0.89 -0.3
3,853,940 + -0.2
3,853,941 - +0.5
3,853,941 - +0.3
3,853,941 - +1.5
3,853,991 + -0.2
3,853,991 + +0.0
3,853,991 + -0.7
3,853,991 + -0.1
3,853,992 - +0.1
3,853,992 - -1.0
3,853,992 - -0.5
3,853,992 - +0.9
3,854,032 + Rv3435c 0.11 +0.2
3,854,120 + Rv3435c 0.21 +0.3
3,854,121 - Rv3435c 0.21 -0.4

Or see this region's nucleotide sequence