Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1538c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1537 and Rv1538c overlap by 36 nucleotidesRv1538c and Rv1539 are separated by 51 nucleotidesRv1539 and Rv1540 overlap by 8 nucleotides Rv1537: Rv1537 - Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)), at 1,739,856 to 1,741,247 Rv1537 Rv1538c: Rv1538c - Probable L-aparaginase AnsA, at 1,741,212 to 1,742,192 Rv1538c Rv1539: Rv1539 - Probable lipoprotein signal peptidase LspA, at 1,742,244 to 1,742,852 Rv1539 Rv1540: Rv1540 - Conserved hypothetical protein member of yabO/yceC/yfiI family, at 1,742,845 to 1,743,771 Rv1540 Position (kb) 1741 1742 1743Strain fitness (log2 ratio) -2 -1 0 1 2at 1740.494 kb on - strand, within Rv1537at 1740.716 kb on - strand, within Rv1537at 1740.739 kb on + strand, within Rv1537at 1740.936 kb on + strand, within Rv1537at 1741.174 kb on - strandat 1741.270 kb on - strandat 1741.348 kb on + strand, within Rv1538cat 1741.610 kb on - strand, within Rv1538cat 1741.867 kb on + strand, within Rv1538cat 1741.868 kb on - strand, within Rv1538cat 1741.868 kb on - strand, within Rv1538cat 1741.904 kb on + strand, within Rv1538cat 1741.972 kb on - strand, within Rv1538cat 1742.028 kb on + strand, within Rv1538cat 1742.029 kb on - strand, within Rv1538cat 1742.029 kb on - strand, within Rv1538cat 1742.091 kb on + strand, within Rv1538cat 1742.136 kb on - strandat 1742.797 kb on + strandat 1742.797 kb on + strandat 1742.797 kb on + strandat 1742.827 kb on + strandat 1742.827 kb on + strandat 1742.827 kb on + strandat 1742.827 kb on + strandat 1742.827 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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1,740,494 - Rv1537 0.46 +1.6
1,740,716 - Rv1537 0.62 -0.1
1,740,739 + Rv1537 0.63 -2.6
1,740,936 + Rv1537 0.78 -0.1
1,741,174 - -1.6
1,741,270 - -0.4
1,741,348 + Rv1538c 0.14 +0.5
1,741,610 - Rv1538c 0.41 +0.6
1,741,867 + Rv1538c 0.67 -0.7
1,741,868 - Rv1538c 0.67 -0.8
1,741,868 - Rv1538c 0.67 +0.6
1,741,904 + Rv1538c 0.71 -1.1
1,741,972 - Rv1538c 0.77 +0.5
1,742,028 + Rv1538c 0.83 +0.7
1,742,029 - Rv1538c 0.83 +1.9
1,742,029 - Rv1538c 0.83 +2.5
1,742,091 + Rv1538c 0.90 +0.8
1,742,136 - +0.6
1,742,797 + -1.4
1,742,797 + -0.4
1,742,797 + -0.1
1,742,827 + -0.4
1,742,827 + -1.1
1,742,827 + -0.3
1,742,827 + +0.1
1,742,827 + -0.3

Or see this region's nucleotide sequence