Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1459c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1458c and Rv1459c are separated by 102 nucleotidesRv1459c and Rv1460 are separated by 47 nucleotidesRv1460 and Rv1461 overlap by 4 nucleotides Rv1458c: Rv1458c - Probable unidentified antibiotic-transport ATP-binding protein ABC transporter, at 1,643,319 to 1,644,260 Rv1458c Rv1459c: Rv1459c - Possible conserved integral membrane protein, at 1,644,363 to 1,646,138 Rv1459c Rv1460: Rv1460 - Probable transcriptional regulatory protein, at 1,646,186 to 1,646,992 Rv1460 Rv1461: Rv1461 - Conserved protein, at 1,646,989 to 1,649,529 Rv1461 Position (kb) 1644 1645 1646 1647Strain fitness (log2 ratio) -1 0 1at 1644.229 kb on - strandat 1644.229 kb on - strandat 1644.379 kb on + strandat 1644.379 kb on + strandat 1644.478 kb on - strandat 1644.487 kb on + strandat 1644.487 kb on + strandat 1644.488 kb on - strandat 1645.252 kb on - strand, within Rv1459cat 1646.121 kb on - strandat 1646.121 kb on - strandat 1646.121 kb on - strandat 1646.150 kb on - strandat 1646.209 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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1,644,229 - +0.1
1,644,229 - +0.7
1,644,379 + +0.1
1,644,379 + -0.2
1,644,478 - -0.2
1,644,487 + +0.5
1,644,487 + +0.4
1,644,488 - +0.1
1,645,252 - Rv1459c 0.50 +0.7
1,646,121 - +0.9
1,646,121 - -0.0
1,646,121 - +0.3
1,646,150 - -0.3
1,646,209 + +0.4

Or see this region's nucleotide sequence