Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0981

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0980c and Rv0981 are separated by 370 nucleotidesRv0981 and Rv0982 overlap by 1 nucleotides Rv0980c: Rv0980c - PE-PGRS family protein PE_PGRS18, at 1,095,078 to 1,096,451 Rv0980c Rv0981: Rv0981 - Mycobacterial persistence regulator MRPA (two component response transcriptional regulatory protein), at 1,096,822 to 1,097,508 Rv0981 Rv0982: Rv0982 - Two component sensor kinase MprB, at 1,097,508 to 1,099,022 Rv0982 Position (kb) 1096 1097 1098Strain fitness (log2 ratio) -1 0 1at 1096.205 kb on + strand, within Rv0980cat 1096.205 kb on + strand, within Rv0980cat 1096.205 kb on + strand, within Rv0980cat 1096.768 kb on + strandat 1096.769 kb on - strandat 1096.769 kb on - strandat 1096.895 kb on - strand, within Rv0981at 1097.114 kb on - strand, within Rv0981at 1097.118 kb on - strand, within Rv0981at 1097.118 kb on - strand, within Rv0981at 1097.364 kb on - strand, within Rv0981at 1097.364 kb on - strand, within Rv0981at 1097.416 kb on + strand, within Rv0981at 1097.417 kb on - strand, within Rv0981at 1097.420 kb on + strand, within Rv0981at 1097.420 kb on + strand, within Rv0981at 1097.421 kb on - strand, within Rv0981at 1097.421 kb on - strand, within Rv0981at 1097.421 kb on - strand, within Rv0981at 1097.482 kb on + strandat 1097.490 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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1,096,205 + Rv0980c 0.82 -0.6
1,096,205 + Rv0980c 0.82 -0.6
1,096,205 + Rv0980c 0.82 -0.4
1,096,768 + -1.3
1,096,769 - -0.1
1,096,769 - -0.4
1,096,895 - Rv0981 0.11 -0.1
1,097,114 - Rv0981 0.43 +1.3
1,097,118 - Rv0981 0.43 +0.9
1,097,118 - Rv0981 0.43 -0.4
1,097,364 - Rv0981 0.79 +0.4
1,097,364 - Rv0981 0.79 -0.4
1,097,416 + Rv0981 0.86 -0.5
1,097,417 - Rv0981 0.87 -0.3
1,097,420 + Rv0981 0.87 -0.1
1,097,420 + Rv0981 0.87 +0.7
1,097,421 - Rv0981 0.87 +1.1
1,097,421 - Rv0981 0.87 +0.2
1,097,421 - Rv0981 0.87 +0.1
1,097,482 + -0.2
1,097,490 - +0.3

Or see this region's nucleotide sequence