Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0493c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0492c and Rv0492A overlap by 4 nucleotidesRv0492A and Rv0493c overlap by 4 nucleotidesRv0493c and Rv0494 are separated by 4 nucleotidesRv0494 and Rv0495c are separated by 0 nucleotides Rv0492c: Rv0492c - Probable oxidoreductase GMC-type, at 581,489 to 583,378 Rv0492c Rv0492A: Rv0492A - Hypothetical protein, at 583,375 to 583,704 Rv0492A Rv0493c: Rv0493c - Conserved protein, at 583,701 to 584,690 Rv0493c Rv0494: Rv0494 - Probable transcriptional regulatory protein (probably GntR-family), at 584,695 to 585,423 Rv0494 Rv0495c: Rv0495c - Conserved hypothetical protein, at 585,424 to 586,314 Rv0495c Position (kb) 583 584 585Strain fitness (log2 ratio) -2 -1 0 1at 582.783 kb on + strand, within Rv0492cat 582.783 kb on + strand, within Rv0492cat 582.784 kb on - strand, within Rv0492cat 582.795 kb on + strand, within Rv0492cat 583.042 kb on - strand, within Rv0492cat 583.189 kb on - strand, within Rv0492cat 583.189 kb on - strand, within Rv0492cat 583.260 kb on + strandat 583.261 kb on - strandat 583.348 kb on - strandat 583.408 kb on + strand, within Rv0492Aat 583.408 kb on + strand, within Rv0492Aat 583.422 kb on - strand, within Rv0492Aat 583.571 kb on + strand, within Rv0492Aat 583.572 kb on - strand, within Rv0492Aat 583.864 kb on + strand, within Rv0493cat 583.865 kb on - strand, within Rv0493cat 583.876 kb on - strand, within Rv0493cat 583.876 kb on - strand, within Rv0493cat 583.876 kb on - strand, within Rv0493cat 584.055 kb on + strand, within Rv0493cat 584.073 kb on + strand, within Rv0493cat 584.091 kb on + strand, within Rv0493cat 584.155 kb on + strand, within Rv0493cat 584.155 kb on + strand, within Rv0493cat 584.155 kb on + strand, within Rv0493cat 584.155 kb on + strand, within Rv0493cat 584.155 kb on + strand, within Rv0493cat 584.156 kb on - strand, within Rv0493cat 584.156 kb on - strand, within Rv0493cat 584.156 kb on - strand, within Rv0493cat 584.355 kb on - strand, within Rv0493cat 584.385 kb on + strand, within Rv0493cat 584.385 kb on + strand, within Rv0493cat 584.500 kb on + strand, within Rv0493cat 584.544 kb on + strand, within Rv0493cat 584.545 kb on - strand, within Rv0493cat 584.582 kb on - strand, within Rv0493cat 584.582 kb on - strand, within Rv0493cat 584.582 kb on - strand, within Rv0493cat 585.041 kb on + strand, within Rv0494at 585.042 kb on - strand, within Rv0494at 585.169 kb on + strand, within Rv0494at 585.170 kb on - strand, within Rv0494at 585.274 kb on + strand, within Rv0494at 585.275 kb on - strand, within Rv0494at 585.370 kb on + strandat 585.422 kb on - strandat 585.422 kb on - strandat 585.422 kb on - strandat 585.426 kb on - strandat 585.426 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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582,783 + Rv0492c 0.68 -0.6
582,783 + Rv0492c 0.68 -1.5
582,784 - Rv0492c 0.69 +0.2
582,795 + Rv0492c 0.69 -1.4
583,042 - Rv0492c 0.82 -1.1
583,189 - Rv0492c 0.90 +1.5
583,189 - Rv0492c 0.90 -0.2
583,260 + -0.9
583,261 - -0.1
583,348 - +0.9
583,408 + Rv0492A 0.10 +0.0
583,408 + Rv0492A 0.10 +0.6
583,422 - Rv0492A 0.14 -0.3
583,571 + Rv0492A 0.59 +1.4
583,572 - Rv0492A 0.60 -0.6
583,864 + Rv0493c 0.16 +0.4
583,865 - Rv0493c 0.17 -0.1
583,876 - Rv0493c 0.18 -0.6
583,876 - Rv0493c 0.18 -0.1
583,876 - Rv0493c 0.18 -0.3
584,055 + Rv0493c 0.36 -0.2
584,073 + Rv0493c 0.38 -0.4
584,091 + Rv0493c 0.39 -0.9
584,155 + Rv0493c 0.46 -0.0
584,155 + Rv0493c 0.46 -0.4
584,155 + Rv0493c 0.46 +0.8
584,155 + Rv0493c 0.46 +0.6
584,155 + Rv0493c 0.46 -0.4
584,156 - Rv0493c 0.46 -0.1
584,156 - Rv0493c 0.46 -0.9
584,156 - Rv0493c 0.46 +0.2
584,355 - Rv0493c 0.66 -0.3
584,385 + Rv0493c 0.69 -1.8
584,385 + Rv0493c 0.69 -1.0
584,500 + Rv0493c 0.81 -0.7
584,544 + Rv0493c 0.85 -0.9
584,545 - Rv0493c 0.85 -0.9
584,582 - Rv0493c 0.89 -0.3
584,582 - Rv0493c 0.89 -0.8
584,582 - Rv0493c 0.89 -0.3
585,041 + Rv0494 0.47 -0.3
585,042 - Rv0494 0.48 -0.4
585,169 + Rv0494 0.65 -1.0
585,170 - Rv0494 0.65 -2.4
585,274 + Rv0494 0.79 -0.1
585,275 - Rv0494 0.80 -0.8
585,370 + -0.5
585,422 - -0.1
585,422 - -0.3
585,422 - +0.5
585,426 - -0.3
585,426 - -1.6

Or see this region's nucleotide sequence