Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3468c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3467 and Rv3468c are separated by 57 nucleotidesRv3468c and Rv3469c are separated by 3 nucleotides Rv3466: Rv3466 - Conserved hypothetical protein, at 3,883,525 to 3,884,193 Rv3466 Rv3467: Rv3467 - Conserved hypothetical protein, at 3,883,964 to 3,884,917 Rv3467 Rv3468c: Rv3468c - Possible dTDP-glucose 4,6-dehydratase, at 3,884,975 to 3,886,069 Rv3468c Rv3469c: Rv3469c - Probable 4-hydroxy-2-oxovalerate aldolase MhpE (HOA), at 3,886,073 to 3,887,083 Rv3469c Position (kb) 3884 3885 3886 3887Strain fitness (log2 ratio) -1 0 1 2 3 4at 3885.010 kb on - strandat 3885.535 kb on + strand, within Rv3468cat 3885.535 kb on + strand, within Rv3468cat 3885.536 kb on - strand, within Rv3468cat 3885.552 kb on + strand, within Rv3468cat 3885.552 kb on + strand, within Rv3468cat 3885.553 kb on - strand, within Rv3468cat 3885.553 kb on - strand, within Rv3468cat 3886.292 kb on - strand, within Rv3469cat 3886.539 kb on + strand, within Rv3469cat 3886.576 kb on + strand, within Rv3469cat 3886.577 kb on - strand, within Rv3469cat 3886.751 kb on + strand, within Rv3469cat 3886.751 kb on + strand, within Rv3469cat 3886.752 kb on - strand, within Rv3469cat 3886.752 kb on - strand, within Rv3469cat 3886.870 kb on - strand, within Rv3469cat 3886.870 kb on - strand, within Rv3469cat 3887.019 kb on + strandat 3887.019 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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3,885,010 - -0.4
3,885,535 + Rv3468c 0.51 -0.0
3,885,535 + Rv3468c 0.51 +1.7
3,885,536 - Rv3468c 0.51 -0.4
3,885,552 + Rv3468c 0.53 +4.1
3,885,552 + Rv3468c 0.53 +0.4
3,885,553 - Rv3468c 0.53 -0.6
3,885,553 - Rv3468c 0.53 +0.1
3,886,292 - Rv3469c 0.22 +0.3
3,886,539 + Rv3469c 0.46 +0.6
3,886,576 + Rv3469c 0.50 -0.5
3,886,577 - Rv3469c 0.50 +0.5
3,886,751 + Rv3469c 0.67 -0.4
3,886,751 + Rv3469c 0.67 -0.0
3,886,752 - Rv3469c 0.67 -0.0
3,886,752 - Rv3469c 0.67 +0.6
3,886,870 - Rv3469c 0.79 +0.3
3,886,870 - Rv3469c 0.79 -1.4
3,887,019 + -0.1
3,887,019 + -0.8

Or see this region's nucleotide sequence