Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0045c

Experiment: 7H9 with Streptomycin 0.178 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0043c and Rv0044c are separated by 132 nucleotidesRv0044c and Rv0045c are separated by 15 nucleotidesRv0045c and Rv0046c are separated by 81 nucleotides Rv0043c: Rv0043c - Probable transcriptional regulatory protein (probably GntR-family), at 47,366 to 48,100 Rv0043c Rv0044c: Rv0044c - Possible oxidoreductase, at 48,233 to 49,027 Rv0044c Rv0045c: Rv0045c - Possible hydrolase, at 49,043 to 49,939 Rv0045c Rv0046c: Rv0046c - myo-inositol-1-phosphate synthase Ino1 (inositol 1-phosphate synthetase) (D-glucose 6-phosphate cycloaldolase) (glucose 6-phosphate cyclase) (glucocycloaldolase), at 50,021 to 51,124 Rv0046c Position (kb) 49 50Strain fitness (log2 ratio) -1 0 1 2at 48.104 kb on + strandat 48.105 kb on - strandat 48.105 kb on - strandat 48.108 kb on + strandat 48.108 kb on + strandat 48.109 kb on - strandat 48.109 kb on - strandat 48.446 kb on + strand, within Rv0044cat 48.451 kb on - strand, within Rv0044cat 48.490 kb on - strand, within Rv0044cat 48.514 kb on + strand, within Rv0044cat 48.514 kb on + strand, within Rv0044cat 48.515 kb on - strand, within Rv0044cat 48.731 kb on - strand, within Rv0044cat 48.766 kb on - strand, within Rv0044cat 48.766 kb on - strand, within Rv0044cat 48.783 kb on - strand, within Rv0044cat 48.896 kb on - strand, within Rv0044cat 48.954 kb on + strandat 48.983 kb on + strandat 48.984 kb on - strandat 48.984 kb on - strandat 48.992 kb on - strandat 49.039 kb on - strandat 49.657 kb on - strand, within Rv0045cat 49.750 kb on + strand, within Rv0045cat 49.750 kb on + strand, within Rv0045cat 49.751 kb on - strand, within Rv0045cat 49.751 kb on - strand, within Rv0045cat 49.751 kb on - strand, within Rv0045cat 49.935 kb on - strandat 49.935 kb on - strandat 49.973 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Streptomycin 0.178 ug/mL
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48,104 + +2.1
48,105 - -1.5
48,105 - -1.3
48,108 + -0.0
48,108 + -1.1
48,109 - -0.2
48,109 - -0.0
48,446 + Rv0044c 0.27 -0.0
48,451 - Rv0044c 0.27 -0.2
48,490 - Rv0044c 0.32 +0.8
48,514 + Rv0044c 0.35 -0.4
48,514 + Rv0044c 0.35 -1.0
48,515 - Rv0044c 0.35 -0.5
48,731 - Rv0044c 0.63 -0.3
48,766 - Rv0044c 0.67 +0.1
48,766 - Rv0044c 0.67 -0.5
48,783 - Rv0044c 0.69 +0.2
48,896 - Rv0044c 0.83 +0.2
48,954 + +1.0
48,983 + -1.2
48,984 - -0.9
48,984 - -0.7
48,992 - -0.3
49,039 - +1.0
49,657 - Rv0045c 0.68 +1.7
49,750 + Rv0045c 0.79 -0.1
49,750 + Rv0045c 0.79 -0.3
49,751 - Rv0045c 0.79 -0.1
49,751 - Rv0045c 0.79 -1.1
49,751 - Rv0045c 0.79 -0.1
49,935 - -0.1
49,935 - +0.3
49,973 + -0.2

Or see this region's nucleotide sequence