Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3176c

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3175 and Rv3176c overlap by 4 nucleotidesRv3176c and Rv3177 are separated by 146 nucleotides Rv3175: Rv3175 - Possible amidase (aminohydrolase), at 3,542,860 to 3,544,347 Rv3175 Rv3176c: Rv3176c - Probable epoxide hydrolase MesT (epoxide hydratase) (arene-oxide hydratase), at 3,544,344 to 3,545,300 Rv3176c Rv3177: Rv3177 - Possible peroxidase (non-haem peroxidase), at 3,545,447 to 3,546,307 Rv3177 Position (kb) 3544 3545 3546Strain fitness (log2 ratio) -1 0 1 2 3 4at 3543.395 kb on - strand, within Rv3175at 3543.635 kb on - strand, within Rv3175at 3543.963 kb on - strand, within Rv3175at 3544.151 kb on - strand, within Rv3175at 3544.230 kb on + strandat 3544.289 kb on + strandat 3544.289 kb on + strandat 3544.290 kb on - strandat 3544.346 kb on - strandat 3544.346 kb on - strandat 3544.371 kb on - strandat 3544.927 kb on + strand, within Rv3176cat 3545.017 kb on + strand, within Rv3176cat 3545.054 kb on - strand, within Rv3176cat 3545.063 kb on - strand, within Rv3176cat 3545.119 kb on + strand, within Rv3176cat 3545.119 kb on + strand, within Rv3176cat 3545.181 kb on + strand, within Rv3176cat 3545.181 kb on + strand, within Rv3176cat 3545.181 kb on + strand, within Rv3176cat 3545.392 kb on + strandat 3545.401 kb on + strandat 3545.401 kb on + strandat 3545.484 kb on - strandat 3545.534 kb on + strand, within Rv3177

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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3,543,395 - Rv3175 0.36 -0.4
3,543,635 - Rv3175 0.52 -0.5
3,543,963 - Rv3175 0.74 +2.5
3,544,151 - Rv3175 0.87 +0.0
3,544,230 + +0.6
3,544,289 + +0.7
3,544,289 + +0.4
3,544,290 - +0.7
3,544,346 - -0.0
3,544,346 - -0.9
3,544,371 - +0.1
3,544,927 + Rv3176c 0.61 +0.7
3,545,017 + Rv3176c 0.70 -0.9
3,545,054 - Rv3176c 0.74 +0.3
3,545,063 - Rv3176c 0.75 -0.7
3,545,119 + Rv3176c 0.81 -0.7
3,545,119 + Rv3176c 0.81 +0.9
3,545,181 + Rv3176c 0.87 +4.2
3,545,181 + Rv3176c 0.87 -0.5
3,545,181 + Rv3176c 0.87 +0.3
3,545,392 + -0.4
3,545,401 + -0.2
3,545,401 + +1.7
3,545,484 - +0.3
3,545,534 + Rv3177 0.10 +0.1

Or see this region's nucleotide sequence