Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2042c

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2041c and Rv2042c are separated by 37 nucleotidesRv2042c and Rv2043c overlap by 1 nucleotidesRv2043c and Rv2044c are separated by 40 nucleotides Rv2041c: Rv2041c - Probable sugar-binding lipoprotein, at 2,286,527 to 2,287,846 Rv2041c Rv2042c: Rv2042c - Conserved protein, at 2,287,884 to 2,288,681 Rv2042c Rv2043c: Rv2043c - Pyrazinamidase/nicotinamidase PncA (PZase), at 2,288,681 to 2,289,241 Rv2043c Rv2044c: Rv2044c - Conserved hypothetical protein, at 2,289,282 to 2,289,599 Rv2044c Position (kb) 2287 2288 2289Strain fitness (log2 ratio) -1 0 1at 2286.889 kb on + strand, within Rv2041cat 2287.095 kb on + strand, within Rv2041cat 2287.172 kb on + strand, within Rv2041cat 2287.173 kb on - strand, within Rv2041cat 2287.324 kb on + strand, within Rv2041cat 2287.410 kb on + strand, within Rv2041cat 2287.644 kb on - strand, within Rv2041cat 2287.874 kb on - strandat 2288.108 kb on - strand, within Rv2042cat 2288.233 kb on - strand, within Rv2042cat 2288.372 kb on - strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.376 kb on + strand, within Rv2042cat 2288.846 kb on - strand, within Rv2043cat 2288.958 kb on + strand, within Rv2043cat 2289.141 kb on + strand, within Rv2043cat 2289.241 kb on + strandat 2289.241 kb on + strandat 2289.242 kb on - strandat 2289.252 kb on + strandat 2289.253 kb on - strandat 2289.306 kb on + strandat 2289.307 kb on - strandat 2289.391 kb on + strand, within Rv2044cat 2289.578 kb on - strandat 2289.612 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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2,286,889 + Rv2041c 0.27 +0.0
2,287,095 + Rv2041c 0.43 +0.7
2,287,172 + Rv2041c 0.49 -0.8
2,287,173 - Rv2041c 0.49 -0.6
2,287,324 + Rv2041c 0.60 -0.2
2,287,410 + Rv2041c 0.67 +0.3
2,287,644 - Rv2041c 0.85 -0.4
2,287,874 - +0.1
2,288,108 - Rv2042c 0.28 +1.7
2,288,233 - Rv2042c 0.44 -0.2
2,288,372 - Rv2042c 0.61 -0.3
2,288,376 + Rv2042c 0.62 +1.1
2,288,376 + Rv2042c 0.62 +0.7
2,288,846 - Rv2043c 0.29 -0.1
2,288,958 + Rv2043c 0.49 -0.1
2,289,141 + Rv2043c 0.82 -0.4
2,289,241 + -0.2
2,289,241 + -0.3
2,289,242 - -0.2
2,289,252 + -1.0
2,289,253 - -0.2
2,289,306 + +0.3
2,289,307 - +0.2
2,289,391 + Rv2044c 0.34 +0.4
2,289,578 - -0.0
2,289,612 + -1.0

Or see this region's nucleotide sequence