Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2035

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2033c and Rv2034 are separated by 211 nucleotidesRv2034 and Rv2035 overlap by 4 nucleotidesRv2035 and Rv2036 overlap by 4 nucleotidesRv2036 and Rv2037c are separated by 6 nucleotides Rv2033c: Rv2033c - Conserved hypothetical protein, at 2,280,240 to 2,281,082 Rv2033c Rv2034: Rv2034 - ArsR repressor protein, at 2,281,294 to 2,281,617 Rv2034 Rv2035: Rv2035 - Conserved hypothetical protein, at 2,281,614 to 2,282,102 Rv2035 Rv2036: Rv2036 - Conserved hypothetical protein, at 2,282,099 to 2,282,740 Rv2036 Rv2037c: Rv2037c - Conserved transmembrane protein, at 2,282,747 to 2,283,721 Rv2037c Position (kb) 2281 2282 2283Strain fitness (log2 ratio) -2 -1 0 1at 2280.748 kb on + strand, within Rv2033cat 2280.877 kb on - strand, within Rv2033cat 2280.880 kb on + strand, within Rv2033cat 2281.090 kb on + strandat 2281.090 kb on + strandat 2281.090 kb on + strandat 2281.091 kb on - strandat 2281.155 kb on - strandat 2281.785 kb on - strand, within Rv2035at 2281.788 kb on + strand, within Rv2035at 2281.839 kb on + strand, within Rv2035at 2281.840 kb on - strand, within Rv2035at 2281.861 kb on + strand, within Rv2035at 2282.055 kb on + strandat 2282.056 kb on - strandat 2282.059 kb on + strandat 2282.068 kb on - strandat 2282.070 kb on - strandat 2282.166 kb on + strand, within Rv2036at 2282.748 kb on + strandat 2282.788 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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2,280,748 + Rv2033c 0.60 +0.1
2,280,877 - Rv2033c 0.76 -0.1
2,280,880 + Rv2033c 0.76 +0.5
2,281,090 + -0.1
2,281,090 + -0.0
2,281,090 + +0.0
2,281,091 - -1.1
2,281,155 - -0.4
2,281,785 - Rv2035 0.35 +0.0
2,281,788 + Rv2035 0.36 -0.3
2,281,839 + Rv2035 0.46 -0.1
2,281,840 - Rv2035 0.46 -0.6
2,281,861 + Rv2035 0.51 +1.5
2,282,055 + -0.0
2,282,056 - -0.6
2,282,059 + -1.4
2,282,068 - -0.1
2,282,070 - -0.7
2,282,166 + Rv2036 0.10 -1.9
2,282,748 + -0.9
2,282,788 - -0.0

Or see this region's nucleotide sequence