Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1944c

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1941 and Rv1942c are separated by 209 nucleotidesRv1942c and Rv1943c overlap by 4 nucleotidesRv1943c and Rv1944c overlap by 4 nucleotidesRv1944c and Rv1945 are separated by 54 nucleotides Rv1941: Rv1941 - Probable short-chain type dehydrogenase/reductase, at 2,193,664 to 2,194,434 Rv1941 Rv1942c: Rv1942c - Possible toxin MazF5, at 2,194,644 to 2,194,973 Rv1942c Rv1943c: Rv1943c - Possible antitoxin MazE5, at 2,194,970 to 2,195,347 Rv1943c Rv1944c: Rv1944c - Conserved protein, at 2,195,344 to 2,195,934 Rv1944c Rv1945: Rv1945 - Conserved hypothetical protein, at 2,195,989 to 2,197,353 Rv1945 Position (kb) 2195 2196Strain fitness (log2 ratio) -1 0 1at 2194.493 kb on + strandat 2195.004 kb on - strandat 2195.055 kb on + strand, within Rv1943cat 2195.056 kb on - strand, within Rv1943cat 2195.056 kb on - strand, within Rv1943cat 2195.490 kb on - strand, within Rv1944cat 2195.636 kb on + strand, within Rv1944cat 2195.868 kb on - strand, within Rv1944c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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2,194,493 + -0.3
2,195,004 - -0.1
2,195,055 + Rv1943c 0.22 +0.7
2,195,056 - Rv1943c 0.23 -0.4
2,195,056 - Rv1943c 0.23 -0.5
2,195,490 - Rv1944c 0.25 -0.5
2,195,636 + Rv1944c 0.49 +0.4
2,195,868 - Rv1944c 0.89 +1.4

Or see this region's nucleotide sequence