Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3491

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3490 and Rv3491 are separated by 151 nucleotidesRv3491 and Rv3492c overlap by 4 nucleotidesRv3492c and Rv3493c overlap by 1 nucleotides Rv3490: Rv3490 - Alpha, alpha-trehalose-phosphate synthase [UDP-forming] OtsA (trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-UDP glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-UDP glucosyl transferase), at 3,908,236 to 3,909,738 Rv3490 Rv3491: Rv3491 - Unknown protein, at 3,909,890 to 3,910,468 Rv3491 Rv3492c: Rv3492c - Conserved hypothetical Mce associated protein, at 3,910,465 to 3,910,947 Rv3492c Rv3493c: Rv3493c - Conserved hypothetical Mce associated alanine and valine rich protein, at 3,910,947 to 3,911,675 Rv3493c Position (kb) 3909 3910 3911Strain fitness (log2 ratio) -1 0 1at 3909.737 kb on - strandat 3909.855 kb on + strandat 3910.084 kb on + strand, within Rv3491at 3910.085 kb on - strand, within Rv3491at 3910.097 kb on + strand, within Rv3491at 3910.148 kb on - strand, within Rv3491at 3910.213 kb on + strand, within Rv3491at 3910.214 kb on - strand, within Rv3491at 3910.214 kb on - strand, within Rv3491at 3910.214 kb on - strand, within Rv3491at 3910.295 kb on + strand, within Rv3491at 3910.296 kb on - strand, within Rv3491at 3910.819 kb on + strand, within Rv3492cat 3911.060 kb on + strand, within Rv3493cat 3911.179 kb on - strand, within Rv3493cat 3911.179 kb on - strand, within Rv3493cat 3911.287 kb on + strand, within Rv3493cat 3911.375 kb on + strand, within Rv3493c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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3,909,737 - +1.5
3,909,855 + -0.4
3,910,084 + Rv3491 0.34 -0.8
3,910,085 - Rv3491 0.34 -0.3
3,910,097 + Rv3491 0.36 +0.9
3,910,148 - Rv3491 0.45 -0.0
3,910,213 + Rv3491 0.56 -0.2
3,910,214 - Rv3491 0.56 -0.2
3,910,214 - Rv3491 0.56 -0.6
3,910,214 - Rv3491 0.56 +0.2
3,910,295 + Rv3491 0.70 +1.1
3,910,296 - Rv3491 0.70 -0.6
3,910,819 + Rv3492c 0.73 -0.9
3,911,060 + Rv3493c 0.16 +0.3
3,911,179 - Rv3493c 0.32 -1.6
3,911,179 - Rv3493c 0.32 -0.3
3,911,287 + Rv3493c 0.47 -0.9
3,911,375 + Rv3493c 0.59 -0.2

Or see this region's nucleotide sequence