Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3445c

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3442c and Rv3443c overlap by 4 nucleotidesRv3443c and Rv3444c are separated by 233 nucleotidesRv3444c and Rv3445c are separated by 20 nucleotidesRv3445c and Rv3446c are separated by 52 nucleotides Rv3442c: Rv3442c - 30S ribosomal protein S9 RpsI, at 3,861,495 to 3,861,950 Rv3442c Rv3443c: Rv3443c - 50S ribosomal protein L13 RplM, at 3,861,947 to 3,862,390 Rv3443c Rv3444c: Rv3444c - Putative ESAT-6 like protein EsxT, at 3,862,624 to 3,862,926 Rv3444c Rv3445c: Rv3445c - ESAT-6 like protein EsxU, at 3,862,947 to 3,863,264 Rv3445c Rv3446c: Rv3446c - Hypothetical alanine and valine rich protein, at 3,863,317 to 3,864,531 Rv3446c Position (kb) 3862 3863 3864Strain fitness (log2 ratio) -1 0 1 2 3at 3862.626 kb on - strandat 3862.626 kb on - strandat 3862.950 kb on + strandat 3862.951 kb on - strandat 3863.056 kb on + strand, within Rv3445cat 3863.057 kb on - strand, within Rv3445cat 3863.057 kb on - strand, within Rv3445cat 3863.272 kb on - strandat 3863.341 kb on + strandat 3863.471 kb on + strand, within Rv3446cat 3863.472 kb on - strand, within Rv3446cat 3863.524 kb on + strand, within Rv3446cat 3863.525 kb on - strand, within Rv3446cat 3863.650 kb on + strand, within Rv3446cat 3864.048 kb on + strand, within Rv3446cat 3864.049 kb on - strand, within Rv3446cat 3864.079 kb on + strand, within Rv3446c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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3,862,626 - -0.0
3,862,626 - -0.6
3,862,950 + +0.1
3,862,951 - -0.2
3,863,056 + Rv3445c 0.34 +0.2
3,863,057 - Rv3445c 0.35 -1.7
3,863,057 - Rv3445c 0.35 +2.1
3,863,272 - -0.1
3,863,341 + -0.1
3,863,471 + Rv3446c 0.13 -0.6
3,863,472 - Rv3446c 0.13 -0.0
3,863,524 + Rv3446c 0.17 +0.2
3,863,525 - Rv3446c 0.17 -0.2
3,863,650 + Rv3446c 0.27 -0.3
3,864,048 + Rv3446c 0.60 -0.0
3,864,049 - Rv3446c 0.60 -1.3
3,864,079 + Rv3446c 0.63 +2.8

Or see this region's nucleotide sequence