Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3308

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3306c and Rv3307 are separated by 64 nucleotidesRv3307 and Rv3308 are separated by 3 nucleotidesRv3308 and Rv3309c are separated by 1 nucleotidesRv3309c and Rv3310 are separated by 104 nucleotides Rv3306c: Rv3306c - Probable amidohydrolase AmiB1 (aminohydrolase), at 3,692,805 to 3,693,989 Rv3306c Rv3307: Rv3307 - Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP), at 3,694,054 to 3,694,860 Rv3307 Rv3308: Rv3308 - Probable phosphomannomutase PmmB (phosphomannose mutase), at 3,694,864 to 3,696,468 Rv3308 Rv3309c: Rv3309c - Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase), at 3,696,470 to 3,697,093 Rv3309c Rv3310: Rv3310 - Acid phosphatase (acid phosphomonoesterase) (phosphomonoesterase) (glycerophosphatase), at 3,697,198 to 3,698,097 Rv3310 Position (kb) 3694 3695 3696 3697Strain fitness (log2 ratio) -1 0 1 2at 3693.998 kb on + strandat 3694.040 kb on + strandat 3694.268 kb on + strand, within Rv3307at 3694.349 kb on - strand, within Rv3307at 3694.396 kb on - strand, within Rv3307at 3694.396 kb on - strand, within Rv3307at 3694.396 kb on - strand, within Rv3307at 3694.532 kb on - strand, within Rv3307at 3694.615 kb on + strand, within Rv3307at 3694.615 kb on + strand, within Rv3307at 3694.730 kb on + strand, within Rv3307at 3694.858 kb on + strandat 3695.300 kb on - strand, within Rv3308at 3695.309 kb on - strand, within Rv3308at 3695.452 kb on - strand, within Rv3308at 3695.452 kb on - strand, within Rv3308at 3695.452 kb on - strand, within Rv3308at 3695.578 kb on - strand, within Rv3308at 3696.142 kb on + strand, within Rv3308at 3696.364 kb on + strandat 3696.523 kb on - strandat 3696.523 kb on - strandat 3696.726 kb on - strand, within Rv3309cat 3696.972 kb on + strand, within Rv3309cat 3696.972 kb on + strand, within Rv3309cat 3696.972 kb on + strand, within Rv3309cat 3696.973 kb on - strand, within Rv3309cat 3697.107 kb on - strandat 3697.107 kb on - strandat 3697.107 kb on - strandat 3697.109 kb on - strandat 3697.110 kb on + strandat 3697.111 kb on - strandat 3697.111 kb on - strandat 3697.111 kb on - strandat 3697.187 kb on - strandat 3697.187 kb on - strandat 3697.188 kb on + strandat 3697.189 kb on - strandat 3697.189 kb on - strandat 3697.241 kb on + strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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3,693,998 + -0.0
3,694,040 + +2.0
3,694,268 + Rv3307 0.27 -0.9
3,694,349 - Rv3307 0.37 -0.4
3,694,396 - Rv3307 0.42 -0.6
3,694,396 - Rv3307 0.42 +0.4
3,694,396 - Rv3307 0.42 -0.3
3,694,532 - Rv3307 0.59 +0.8
3,694,615 + Rv3307 0.70 -0.0
3,694,615 + Rv3307 0.70 -0.8
3,694,730 + Rv3307 0.84 +0.0
3,694,858 + -0.4
3,695,300 - Rv3308 0.27 -0.0
3,695,309 - Rv3308 0.28 -0.9
3,695,452 - Rv3308 0.37 -1.0
3,695,452 - Rv3308 0.37 +0.5
3,695,452 - Rv3308 0.37 -0.4
3,695,578 - Rv3308 0.44 -0.3
3,696,142 + Rv3308 0.80 -0.6
3,696,364 + +0.3
3,696,523 - -0.4
3,696,523 - -0.2
3,696,726 - Rv3309c 0.41 +0.5
3,696,972 + Rv3309c 0.80 +0.3
3,696,972 + Rv3309c 0.80 -0.0
3,696,972 + Rv3309c 0.80 -0.3
3,696,973 - Rv3309c 0.81 -0.7
3,697,107 - +0.0
3,697,107 - +2.6
3,697,107 - -1.3
3,697,109 - -0.8
3,697,110 + -0.1
3,697,111 - -1.0
3,697,111 - +1.0
3,697,111 - +0.7
3,697,187 - -0.3
3,697,187 - +0.5
3,697,188 + +0.1
3,697,189 - -1.6
3,697,189 - -1.3
3,697,241 + +0.1

Or see this region's nucleotide sequence