Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2070c

Experiment: 7H9 with para-aminosalicylic 0.086 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2068c and Rv2069 are separated by 134 nucleotidesRv2069 and Rv2070c overlap by 11 nucleotidesRv2070c and Rv2071c overlap by 4 nucleotidesRv2071c and Rv2072c overlap by 4 nucleotides Rv2068c: Rv2068c - Class a beta-lactamase BlaC, at 2,325,886 to 2,326,809 Rv2068c Rv2069: Rv2069 - RNA polymerase sigma factor, ECF subfamily, SigC, at 2,326,944 to 2,327,501 Rv2069 Rv2070c: Rv2070c - Precorrin-6X reductase CobK, at 2,327,491 to 2,328,225 Rv2070c Rv2071c: Rv2071c - Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase), at 2,328,222 to 2,328,977 Rv2071c Rv2072c: Rv2072c - Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL, at 2,328,974 to 2,330,146 Rv2072c Position (kb) 2327 2328 2329Strain fitness (log2 ratio) -2 -1 0 1 2at 2326.625 kb on + strand, within Rv2068cat 2326.625 kb on + strand, within Rv2068cat 2326.625 kb on + strand, within Rv2068cat 2326.625 kb on + strand, within Rv2068cat 2326.625 kb on + strand, within Rv2068cat 2326.625 kb on + strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.626 kb on - strand, within Rv2068cat 2326.646 kb on + strand, within Rv2068cat 2326.646 kb on + strand, within Rv2068cat 2326.647 kb on - strand, within Rv2068cat 2326.647 kb on - strand, within Rv2068cat 2326.647 kb on - strand, within Rv2068cat 2326.814 kb on + strandat 2326.815 kb on - strandat 2326.815 kb on - strandat 2326.815 kb on - strandat 2326.817 kb on + strandat 2326.818 kb on - strandat 2326.818 kb on - strandat 2326.818 kb on - strandat 2326.893 kb on - strandat 2326.907 kb on + strandat 2326.930 kb on + strandat 2326.937 kb on + strandat 2326.937 kb on + strandat 2326.938 kb on - strandat 2327.030 kb on + strand, within Rv2069at 2327.070 kb on + strand, within Rv2069at 2327.070 kb on + strand, within Rv2069at 2327.119 kb on + strand, within Rv2069at 2327.120 kb on - strand, within Rv2069at 2327.269 kb on + strand, within Rv2069at 2327.269 kb on + strand, within Rv2069at 2327.270 kb on - strand, within Rv2069at 2327.706 kb on - strand, within Rv2070cat 2327.712 kb on - strand, within Rv2070cat 2327.725 kb on + strand, within Rv2070cat 2328.232 kb on + strandat 2328.233 kb on - strandat 2328.258 kb on + strandat 2328.258 kb on + strandat 2328.259 kb on - strandat 2328.262 kb on + strandat 2328.262 kb on + strandat 2328.263 kb on - strandat 2328.263 kb on - strandat 2328.883 kb on + strand, within Rv2071cat 2328.933 kb on + strandat 2328.933 kb on + strandat 2328.934 kb on - strandat 2328.934 kb on - strandat 2328.967 kb on + strandat 2328.967 kb on + strandat 2328.968 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with para-aminosalicylic 0.086 ug/mL
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2,326,625 + Rv2068c 0.80 +1.7
2,326,625 + Rv2068c 0.80 +0.8
2,326,625 + Rv2068c 0.80 +0.0
2,326,625 + Rv2068c 0.80 +1.0
2,326,625 + Rv2068c 0.80 -0.5
2,326,625 + Rv2068c 0.80 +0.0
2,326,626 - Rv2068c 0.80 +0.5
2,326,626 - Rv2068c 0.80 -0.6
2,326,626 - Rv2068c 0.80 -0.9
2,326,626 - Rv2068c 0.80 -0.8
2,326,626 - Rv2068c 0.80 -0.7
2,326,626 - Rv2068c 0.80 +0.4
2,326,626 - Rv2068c 0.80 +0.3
2,326,626 - Rv2068c 0.80 -0.8
2,326,646 + Rv2068c 0.82 -1.2
2,326,646 + Rv2068c 0.82 -1.6
2,326,647 - Rv2068c 0.82 -1.3
2,326,647 - Rv2068c 0.82 -1.3
2,326,647 - Rv2068c 0.82 -0.3
2,326,814 + +0.4
2,326,815 - -1.2
2,326,815 - +0.0
2,326,815 - +2.0
2,326,817 + -0.3
2,326,818 - -0.9
2,326,818 - -0.4
2,326,818 - -0.2
2,326,893 - +0.0
2,326,907 + -0.1
2,326,930 + +0.0
2,326,937 + -0.8
2,326,937 + +0.2
2,326,938 - -0.1
2,327,030 + Rv2069 0.15 -0.2
2,327,070 + Rv2069 0.23 -0.3
2,327,070 + Rv2069 0.23 -0.9
2,327,119 + Rv2069 0.31 -0.4
2,327,120 - Rv2069 0.32 +0.2
2,327,269 + Rv2069 0.58 -0.6
2,327,269 + Rv2069 0.58 -0.3
2,327,270 - Rv2069 0.58 +1.0
2,327,706 - Rv2070c 0.29 +0.3
2,327,712 - Rv2070c 0.30 -0.2
2,327,725 + Rv2070c 0.32 +0.6
2,328,232 + -0.1
2,328,233 - -0.4
2,328,258 + +1.0
2,328,258 + +0.3
2,328,259 - -0.2
2,328,262 + -0.8
2,328,262 + +0.1
2,328,263 - -1.8
2,328,263 - -1.1
2,328,883 + Rv2071c 0.87 +0.4
2,328,933 + -0.3
2,328,933 + +0.1
2,328,934 - -0.3
2,328,934 - +0.6
2,328,967 + +0.4
2,328,967 + -0.3
2,328,968 - +0.1

Or see this region's nucleotide sequence