Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3535c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3534c and Rv3535c overlap by 4 nucleotidesRv3535c and Rv3536c are separated by 10 nucleotidesRv3536c and Rv3537 are separated by 72 nucleotides Rv3534c: Rv3534c - Probable 4-hydroxy-2-oxovalerate aldolase (HOA), at 3,972,552 to 3,973,592 Rv3534c Rv3535c: Rv3535c - Probable acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]), at 3,973,589 to 3,974,500 Rv3535c Rv3536c: Rv3536c - Probable hydratase, at 3,974,511 to 3,975,296 Rv3536c Rv3537: Rv3537 - Probable dehydrogenase, at 3,975,369 to 3,977,060 Rv3537 Position (kb) 3973 3974 3975Strain fitness (log2 ratio) -1 0 1 2 3 4at 3972.686 kb on - strand, within Rv3534cat 3972.728 kb on - strand, within Rv3534cat 3972.740 kb on - strand, within Rv3534cat 3973.100 kb on - strand, within Rv3534cat 3973.100 kb on - strand, within Rv3534cat 3973.414 kb on + strand, within Rv3534cat 3973.414 kb on + strand, within Rv3534cat 3973.414 kb on + strand, within Rv3534cat 3973.415 kb on - strand, within Rv3534cat 3973.415 kb on - strand, within Rv3534cat 3973.583 kb on + strandat 3973.604 kb on + strandat 3973.605 kb on - strandat 3973.803 kb on + strand, within Rv3535cat 3973.804 kb on - strand, within Rv3535cat 3973.804 kb on - strand, within Rv3535cat 3974.238 kb on + strand, within Rv3535cat 3974.265 kb on + strand, within Rv3535cat 3974.300 kb on - strand, within Rv3535cat 3974.300 kb on - strand, within Rv3535cat 3974.459 kb on - strandat 3975.058 kb on + strand, within Rv3536cat 3975.058 kb on + strand, within Rv3536cat 3975.058 kb on + strand, within Rv3536cat 3975.116 kb on + strand, within Rv3536cat 3975.116 kb on + strand, within Rv3536cat 3975.116 kb on + strand, within Rv3536cat 3975.117 kb on - strand, within Rv3536cat 3975.256 kb on - strandat 3975.487 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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3,972,686 - Rv3534c 0.13 +0.6
3,972,728 - Rv3534c 0.17 -1.4
3,972,740 - Rv3534c 0.18 -1.2
3,973,100 - Rv3534c 0.53 -1.1
3,973,100 - Rv3534c 0.53 -0.1
3,973,414 + Rv3534c 0.83 -0.1
3,973,414 + Rv3534c 0.83 -0.9
3,973,414 + Rv3534c 0.83 +0.8
3,973,415 - Rv3534c 0.83 +2.0
3,973,415 - Rv3534c 0.83 +4.4
3,973,583 + -0.2
3,973,604 + -0.7
3,973,605 - +0.0
3,973,803 + Rv3535c 0.23 -0.6
3,973,804 - Rv3535c 0.24 -1.1
3,973,804 - Rv3535c 0.24 -1.7
3,974,238 + Rv3535c 0.71 -0.6
3,974,265 + Rv3535c 0.74 -0.6
3,974,300 - Rv3535c 0.78 +0.2
3,974,300 - Rv3535c 0.78 +0.8
3,974,459 - -0.2
3,975,058 + Rv3536c 0.70 -0.1
3,975,058 + Rv3536c 0.70 +2.1
3,975,058 + Rv3536c 0.70 +0.2
3,975,116 + Rv3536c 0.77 +0.2
3,975,116 + Rv3536c 0.77 -1.0
3,975,116 + Rv3536c 0.77 +0.3
3,975,117 - Rv3536c 0.77 +0.7
3,975,256 - -0.4
3,975,487 - -1.0

Or see this region's nucleotide sequence