Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2915c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2914c and Rv2915c are separated by 43 nucleotidesRv2915c and Rv2916c are separated by 27 nucleotides Rv2914c: Rv2914c - Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydroxyalkyl-protein kinase), at 3,221,767 to 3,223,524 Rv2914c Rv2915c: Rv2915c - Conserved protein, at 3,223,568 to 3,224,680 Rv2915c Rv2916c: Rv2916c - Probable signal recognition particle protein Ffh (fifty-four homolog) (SRP protein), at 3,224,708 to 3,226,285 Rv2916c Position (kb) 3223 3224 3225Strain fitness (log2 ratio) -2 -1 0 1 2at 3222.663 kb on - strand, within Rv2914cat 3222.683 kb on + strand, within Rv2914cat 3222.684 kb on - strand, within Rv2914cat 3222.684 kb on - strand, within Rv2914cat 3222.684 kb on - strand, within Rv2914cat 3222.947 kb on - strand, within Rv2914cat 3222.947 kb on - strand, within Rv2914cat 3223.183 kb on + strand, within Rv2914cat 3223.224 kb on + strand, within Rv2914cat 3223.253 kb on + strand, within Rv2914cat 3223.254 kb on - strand, within Rv2914cat 3223.325 kb on - strand, within Rv2914cat 3223.491 kb on - strandat 3223.533 kb on - strandat 3223.535 kb on + strandat 3223.535 kb on + strandat 3223.569 kb on + strandat 3223.772 kb on + strand, within Rv2915cat 3223.827 kb on + strand, within Rv2915cat 3223.828 kb on - strand, within Rv2915cat 3223.869 kb on + strand, within Rv2915cat 3223.882 kb on - strand, within Rv2915cat 3223.906 kb on - strand, within Rv2915cat 3223.915 kb on - strand, within Rv2915cat 3224.298 kb on + strand, within Rv2915cat 3224.298 kb on + strand, within Rv2915cat 3224.298 kb on + strand, within Rv2915cat 3224.298 kb on + strand, within Rv2915cat 3224.566 kb on + strand, within Rv2915cat 3224.567 kb on - strand, within Rv2915cat 3224.567 kb on - strand, within Rv2915cat 3224.710 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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3,222,663 - Rv2914c 0.51 -0.4
3,222,683 + Rv2914c 0.52 -0.3
3,222,684 - Rv2914c 0.52 -0.3
3,222,684 - Rv2914c 0.52 +0.5
3,222,684 - Rv2914c 0.52 -0.8
3,222,947 - Rv2914c 0.67 +0.1
3,222,947 - Rv2914c 0.67 -0.1
3,223,183 + Rv2914c 0.81 -0.7
3,223,224 + Rv2914c 0.83 -1.1
3,223,253 + Rv2914c 0.85 -0.4
3,223,254 - Rv2914c 0.85 -1.2
3,223,325 - Rv2914c 0.89 -0.5
3,223,491 - -0.4
3,223,533 - -1.3
3,223,535 + -0.4
3,223,535 + +1.2
3,223,569 + -0.6
3,223,772 + Rv2915c 0.18 -0.8
3,223,827 + Rv2915c 0.23 -2.4
3,223,828 - Rv2915c 0.23 -0.9
3,223,869 + Rv2915c 0.27 -0.3
3,223,882 - Rv2915c 0.28 +2.1
3,223,906 - Rv2915c 0.30 -0.3
3,223,915 - Rv2915c 0.31 -0.4
3,224,298 + Rv2915c 0.66 +0.5
3,224,298 + Rv2915c 0.66 -0.3
3,224,298 + Rv2915c 0.66 -1.3
3,224,298 + Rv2915c 0.66 -1.2
3,224,566 + Rv2915c 0.90 -1.9
3,224,567 - Rv2915c 0.90 -1.4
3,224,567 - Rv2915c 0.90 -0.1
3,224,710 - +0.1

Or see this region's nucleotide sequence