Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2529

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2528c and Rv2529 are separated by 203 nucleotidesRv2529 and Rv2530c are separated by 0 nucleotidesRv2530c and Rv2530A overlap by 4 nucleotidesRv2530A and Rv2531c are separated by 30 nucleotides Rv2528c: Rv2528c - Probable restriction system protein Mrr, at 2,851,751 to 2,852,671 Rv2528c Rv2529: Rv2529 - Hypothetical protein, at 2,852,875 to 2,854,266 Rv2529 Rv2530c: Rv2530c - Possible toxin VapC39. Contains PIN domain., at 2,854,267 to 2,854,686 Rv2530c Rv2530A: Rv2530A - Possible antitoxin VapB39, at 2,854,683 to 2,854,907 Rv2530A Rv2531c: Rv2531c - Probable amino acid decarboxylase, at 2,854,938 to 2,857,781 Rv2531c Position (kb) 2852 2853 2854 2855Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2852.017 kb on - strand, within Rv2528cat 2852.035 kb on - strand, within Rv2528cat 2852.506 kb on - strand, within Rv2528cat 2852.506 kb on - strand, within Rv2528cat 2852.625 kb on + strandat 2852.724 kb on + strandat 2852.814 kb on + strandat 2852.814 kb on + strandat 2852.828 kb on - strandat 2852.828 kb on - strandat 2852.828 kb on - strandat 2853.439 kb on + strand, within Rv2529at 2853.439 kb on + strand, within Rv2529at 2853.504 kb on - strand, within Rv2529at 2853.935 kb on - strand, within Rv2529at 2854.908 kb on - strandat 2855.040 kb on + strandat 2855.122 kb on + strandat 2855.122 kb on + strandat 2855.122 kb on + strandat 2855.122 kb on + strandat 2855.162 kb on - strandat 2855.162 kb on - strandat 2855.241 kb on + strand, within Rv2531c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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2,852,017 - Rv2528c 0.29 +0.2
2,852,035 - Rv2528c 0.31 +0.2
2,852,506 - Rv2528c 0.82 -1.6
2,852,506 - Rv2528c 0.82 -1.2
2,852,625 + +0.4
2,852,724 + -0.6
2,852,814 + -0.1
2,852,814 + +0.8
2,852,828 - -0.0
2,852,828 - -0.5
2,852,828 - -0.6
2,853,439 + Rv2529 0.41 -0.9
2,853,439 + Rv2529 0.41 +0.4
2,853,504 - Rv2529 0.45 -2.7
2,853,935 - Rv2529 0.76 +0.4
2,854,908 - -1.5
2,855,040 + -0.1
2,855,122 + -0.6
2,855,122 + +0.2
2,855,122 + +0.9
2,855,122 + -0.4
2,855,162 - -2.5
2,855,162 - +0.2
2,855,241 + Rv2531c 0.11 +3.2

Or see this region's nucleotide sequence