Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2089c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2088 and Rv2089c are separated by 16 nucleotidesRv2089c and Rv2090 are separated by 48 nucleotides Rv2088: Rv2088 - Transmembrane serine/threonine-protein kinase J PknJ (protein kinase J) (STPK J), at 2,344,411 to 2,346,180 Rv2088 Rv2089c: Rv2089c - Dipeptidase PepE, at 2,346,197 to 2,347,324 Rv2089c Rv2090: Rv2090 - Probable 5'-3' exonuclease, at 2,347,373 to 2,348,554 Rv2090 Position (kb) 2346 2347 2348Strain fitness (log2 ratio) -1 0 1at 2346.078 kb on + strandat 2346.155 kb on - strandat 2346.171 kb on - strandat 2347.206 kb on + strand, within Rv2089cat 2347.206 kb on + strand, within Rv2089cat 2347.293 kb on + strandat 2347.920 kb on + strand, within Rv2090at 2348.087 kb on + strand, within Rv2090at 2348.266 kb on - strand, within Rv2090at 2348.286 kb on + strand, within Rv2090at 2348.287 kb on - strand, within Rv2090

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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2,346,078 + -0.5
2,346,155 - +0.5
2,346,171 - -0.0
2,347,206 + Rv2089c 0.89 -0.8
2,347,206 + Rv2089c 0.89 -0.6
2,347,293 + -0.9
2,347,920 + Rv2090 0.46 -0.1
2,348,087 + Rv2090 0.60 +0.2
2,348,266 - Rv2090 0.76 -0.3
2,348,286 + Rv2090 0.77 +0.2
2,348,287 - Rv2090 0.77 -1.2

Or see this region's nucleotide sequence