Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1069c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1068c and Rv1069c are separated by 361 nucleotidesRv1069c and Rv1070c overlap by 4 nucleotidesRv1070c and Rv1071c are separated by 11 nucleotides Rv1068c: Rv1068c - PE-PGRS family protein PE_PGRS20, at 1,190,757 to 1,192,148 Rv1068c Rv1069c: Rv1069c - Conserved protein, at 1,192,510 to 1,194,273 Rv1069c Rv1070c: Rv1070c - Probable enoyl-CoA hydratase EchA8 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 1,194,270 to 1,195,043 Rv1070c Rv1071c: Rv1071c - Possible enoyl-CoA hydratase EchA9 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 1,195,055 to 1,196,092 Rv1071c Position (kb) 1192 1193 1194 1195Strain fitness (log2 ratio) -2 -1 0 1 2at 1191.889 kb on + strand, within Rv1068cat 1191.964 kb on + strand, within Rv1068cat 1192.141 kb on + strandat 1192.142 kb on - strandat 1192.142 kb on - strandat 1192.274 kb on - strandat 1192.411 kb on + strandat 1192.628 kb on + strandat 1192.672 kb on - strandat 1192.820 kb on + strand, within Rv1069cat 1192.821 kb on - strand, within Rv1069cat 1192.907 kb on + strand, within Rv1069cat 1193.210 kb on + strand, within Rv1069cat 1193.211 kb on - strand, within Rv1069cat 1193.243 kb on + strand, within Rv1069cat 1193.243 kb on + strand, within Rv1069cat 1193.243 kb on + strand, within Rv1069cat 1193.243 kb on + strand, within Rv1069cat 1193.243 kb on + strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.244 kb on - strand, within Rv1069cat 1193.345 kb on - strand, within Rv1069cat 1193.345 kb on - strand, within Rv1069cat 1193.345 kb on - strand, within Rv1069cat 1193.405 kb on + strand, within Rv1069cat 1193.406 kb on - strand, within Rv1069cat 1193.822 kb on + strand, within Rv1069cat 1193.823 kb on - strand, within Rv1069cat 1193.848 kb on + strand, within Rv1069cat 1193.849 kb on - strand, within Rv1069cat 1193.979 kb on - strand, within Rv1069cat 1193.979 kb on - strand, within Rv1069cat 1193.979 kb on - strand, within Rv1069cat 1193.979 kb on - strand, within Rv1069cat 1194.014 kb on + strand, within Rv1069cat 1194.317 kb on + strandat 1194.317 kb on + strandat 1194.370 kb on + strand, within Rv1070cat 1194.370 kb on + strand, within Rv1070cat 1194.370 kb on + strand, within Rv1070cat 1194.371 kb on - strand, within Rv1070cat 1194.584 kb on + strand, within Rv1070cat 1194.648 kb on + strand, within Rv1070cat 1194.734 kb on - strand, within Rv1070cat 1194.995 kb on + strandat 1195.049 kb on - strandat 1195.057 kb on - strandat 1195.225 kb on - strand, within Rv1071cat 1195.225 kb on - strand, within Rv1071cat 1195.225 kb on - strand, within Rv1071cat 1195.248 kb on - strand, within Rv1071c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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1,191,889 + Rv1068c 0.81 -0.1
1,191,964 + Rv1068c 0.87 +1.3
1,192,141 + +0.5
1,192,142 - +0.4
1,192,142 - +0.0
1,192,274 - -0.1
1,192,411 + -0.7
1,192,628 + +0.0
1,192,672 - +1.2
1,192,820 + Rv1069c 0.18 -0.6
1,192,821 - Rv1069c 0.18 +0.7
1,192,907 + Rv1069c 0.23 +0.2
1,193,210 + Rv1069c 0.40 +0.4
1,193,211 - Rv1069c 0.40 +1.7
1,193,243 + Rv1069c 0.42 +0.4
1,193,243 + Rv1069c 0.42 +0.4
1,193,243 + Rv1069c 0.42 +0.8
1,193,243 + Rv1069c 0.42 +0.2
1,193,243 + Rv1069c 0.42 -0.9
1,193,244 - Rv1069c 0.42 -0.7
1,193,244 - Rv1069c 0.42 +0.4
1,193,244 - Rv1069c 0.42 +0.1
1,193,244 - Rv1069c 0.42 +0.9
1,193,244 - Rv1069c 0.42 +0.3
1,193,244 - Rv1069c 0.42 +0.9
1,193,345 - Rv1069c 0.47 +1.3
1,193,345 - Rv1069c 0.47 +1.3
1,193,345 - Rv1069c 0.47 -0.5
1,193,405 + Rv1069c 0.51 +1.1
1,193,406 - Rv1069c 0.51 +0.9
1,193,822 + Rv1069c 0.74 +0.3
1,193,823 - Rv1069c 0.74 -2.1
1,193,848 + Rv1069c 0.76 +0.8
1,193,849 - Rv1069c 0.76 +0.1
1,193,979 - Rv1069c 0.83 +0.2
1,193,979 - Rv1069c 0.83 -0.2
1,193,979 - Rv1069c 0.83 +0.3
1,193,979 - Rv1069c 0.83 -1.9
1,194,014 + Rv1069c 0.85 +0.8
1,194,317 + +0.1
1,194,317 + +0.7
1,194,370 + Rv1070c 0.13 -0.6
1,194,370 + Rv1070c 0.13 +0.9
1,194,370 + Rv1070c 0.13 -0.1
1,194,371 - Rv1070c 0.13 -0.7
1,194,584 + Rv1070c 0.41 +0.6
1,194,648 + Rv1070c 0.49 -0.2
1,194,734 - Rv1070c 0.60 +0.8
1,194,995 + +0.3
1,195,049 - +0.3
1,195,057 - +0.7
1,195,225 - Rv1071c 0.16 -0.4
1,195,225 - Rv1071c 0.16 -0.5
1,195,225 - Rv1071c 0.16 +2.5
1,195,248 - Rv1071c 0.19 -0.1

Or see this region's nucleotide sequence