Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0805

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0803 and Rv0804 overlap by 4 nucleotidesRv0804 and Rv0805 are separated by 120 nucleotidesRv0805 and Rv0806c overlap by 56 nucleotides Rv0803: Rv0803 - Phosphoribosylformylglycinamidine synthase II PurL (FGAM synthase II), at 895,820 to 898,084 Rv0803 Rv0804: Rv0804 - Conserved hypothetical protein, at 898,081 to 898,710 Rv0804 Rv0805: Rv0805 - Class III cyclic nucleotide phosphodiesterase (cNMP PDE), at 898,831 to 899,787 Rv0805 Rv0806c: Rv0806c - Possible UDP-glucose-4-epimerase CpsY (galactowaldenase) (UDP-galactose-4-epimerase) (uridine diphosphate galactose-4-epimerase) (uridine diphospho-galactose-4-epimerase), at 899,732 to 901,330 Rv0806c Position (kb) 898 899 900Strain fitness (log2 ratio) -2 -1 0 1 2at 898.376 kb on + strand, within Rv0804at 898.376 kb on + strand, within Rv0804at 898.386 kb on + strand, within Rv0804at 898.386 kb on - strand, within Rv0804at 898.386 kb on - strand, within Rv0804at 898.386 kb on - strand, within Rv0804at 898.440 kb on + strand, within Rv0804at 898.479 kb on - strand, within Rv0804at 898.479 kb on - strand, within Rv0804at 898.780 kb on - strandat 898.799 kb on + strandat 898.837 kb on - strandat 898.837 kb on - strandat 898.843 kb on - strandat 898.870 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.880 kb on + strandat 898.881 kb on - strandat 898.884 kb on + strandat 898.884 kb on + strandat 898.884 kb on + strandat 898.885 kb on - strandat 899.028 kb on + strand, within Rv0805at 899.119 kb on - strand, within Rv0805at 899.891 kb on - strandat 899.891 kb on - strandat 899.938 kb on + strand, within Rv0806cat 899.962 kb on - strand, within Rv0806cat 899.980 kb on - strand, within Rv0806cat 899.990 kb on - strand, within Rv0806cat 900.030 kb on + strand, within Rv0806cat 900.033 kb on + strand, within Rv0806cat 900.039 kb on + strand, within Rv0806cat 900.040 kb on - strand, within Rv0806cat 900.040 kb on - strand, within Rv0806cat 900.181 kb on + strand, within Rv0806cat 900.328 kb on + strand, within Rv0806cat 900.434 kb on - strand, within Rv0806cat 900.434 kb on - strand, within Rv0806cat 900.435 kb on + strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.436 kb on - strand, within Rv0806cat 900.552 kb on - strand, within Rv0806cat 900.648 kb on + strand, within Rv0806cat 900.723 kb on - strand, within Rv0806cat 900.784 kb on - strand, within Rv0806c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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898,376 + Rv0804 0.47 +2.4
898,376 + Rv0804 0.47 +1.0
898,386 + Rv0804 0.48 -0.1
898,386 - Rv0804 0.48 +0.1
898,386 - Rv0804 0.48 +0.1
898,386 - Rv0804 0.48 +0.5
898,440 + Rv0804 0.57 +0.2
898,479 - Rv0804 0.63 -0.0
898,479 - Rv0804 0.63 -0.7
898,780 - -2.2
898,799 + +0.1
898,837 - -0.1
898,837 - -0.2
898,843 - -0.7
898,870 + -0.0
898,880 + -0.2
898,880 + -0.5
898,880 + -0.6
898,880 + -0.0
898,881 - -0.2
898,884 + -1.4
898,884 + -1.2
898,884 + +0.8
898,885 - +0.4
899,028 + Rv0805 0.21 -1.2
899,119 - Rv0805 0.30 -1.6
899,891 - -0.8
899,891 - -0.2
899,938 + Rv0806c 0.13 +0.2
899,962 - Rv0806c 0.14 -1.2
899,980 - Rv0806c 0.16 -1.0
899,990 - Rv0806c 0.16 +1.1
900,030 + Rv0806c 0.19 +0.1
900,033 + Rv0806c 0.19 +2.0
900,039 + Rv0806c 0.19 +0.2
900,040 - Rv0806c 0.19 -0.1
900,040 - Rv0806c 0.19 -1.2
900,181 + Rv0806c 0.28 +0.6
900,328 + Rv0806c 0.37 -1.2
900,434 - Rv0806c 0.44 +0.4
900,434 - Rv0806c 0.44 +1.5
900,435 + Rv0806c 0.44 -0.4
900,436 - Rv0806c 0.44 -0.2
900,436 - Rv0806c 0.44 +0.4
900,436 - Rv0806c 0.44 -0.3
900,552 - Rv0806c 0.51 -1.7
900,648 + Rv0806c 0.57 +0.4
900,723 - Rv0806c 0.62 +0.2
900,784 - Rv0806c 0.66 -0.2

Or see this region's nucleotide sequence