Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0743c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0742 and Rv0743c are separated by 377 nucleotidesRv0743c and Rv0744c overlap by 4 nucleotidesRv0744c and Rv0745 are separated by 207 nucleotides Rv0742: Rv0742 - PE-PGRS family protein PE_PGRS8, at 832,981 to 833,508 Rv0742 Rv0743c: Rv0743c - Hypothetical protein, at 833,886 to 834,443 Rv0743c Rv0744c: Rv0744c - Possible transcriptional regulatory protein, at 834,440 to 834,946 Rv0744c Rv0745: Rv0745 - Conserved hypothetical protein, at 835,154 to 835,681 Rv0745 Position (kb) 833 834 835Strain fitness (log2 ratio) -2 -1 0 1 2 3 4at 832.950 kb on + strandat 832.983 kb on - strandat 833.200 kb on - strand, within Rv0742at 833.239 kb on + strand, within Rv0742at 833.239 kb on + strand, within Rv0742at 833.240 kb on - strand, within Rv0742at 833.532 kb on - strandat 833.614 kb on - strandat 833.738 kb on + strandat 833.738 kb on + strandat 833.738 kb on + strandat 833.887 kb on + strandat 833.887 kb on + strandat 833.887 kb on + strandat 833.888 kb on - strandat 833.888 kb on - strandat 833.888 kb on - strandat 833.911 kb on + strandat 833.912 kb on - strandat 833.912 kb on - strandat 833.912 kb on - strandat 833.912 kb on - strandat 833.914 kb on + strandat 833.914 kb on + strandat 833.915 kb on - strandat 833.915 kb on - strandat 833.915 kb on - strandat 834.182 kb on + strand, within Rv0743cat 834.182 kb on + strand, within Rv0743cat 834.182 kb on + strand, within Rv0743cat 834.183 kb on - strand, within Rv0743cat 834.183 kb on - strand, within Rv0743cat 834.183 kb on - strand, within Rv0743cat 834.186 kb on + strand, within Rv0743cat 834.186 kb on + strand, within Rv0743cat 834.186 kb on + strand, within Rv0743cat 834.187 kb on - strand, within Rv0743cat 834.187 kb on - strand, within Rv0743cat 834.187 kb on - strand, within Rv0743cat 834.187 kb on - strand, within Rv0743cat 834.199 kb on + strand, within Rv0743cat 834.327 kb on + strand, within Rv0743cat 834.328 kb on - strand, within Rv0743cat 834.373 kb on - strand, within Rv0743cat 834.524 kb on + strand, within Rv0744cat 834.639 kb on + strand, within Rv0744cat 834.670 kb on + strand, within Rv0744cat 834.909 kb on - strandat 835.016 kb on + strandat 835.017 kb on - strandat 835.060 kb on + strandat 835.061 kb on - strandat 835.130 kb on - strandat 835.222 kb on + strand, within Rv0745

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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832,950 + +0.8
832,983 - +1.0
833,200 - Rv0742 0.41 +0.8
833,239 + Rv0742 0.49 +0.8
833,239 + Rv0742 0.49 -0.4
833,240 - Rv0742 0.49 -1.0
833,532 - -0.2
833,614 - +0.7
833,738 + +0.2
833,738 + -0.4
833,738 + +0.4
833,887 + -0.6
833,887 + -0.5
833,887 + -0.8
833,888 - -0.6
833,888 - +1.1
833,888 - +1.1
833,911 + -0.8
833,912 - +0.8
833,912 - +1.2
833,912 - -0.2
833,912 - +0.0
833,914 + -0.1
833,914 + -0.3
833,915 - +0.4
833,915 - +0.6
833,915 - -0.1
834,182 + Rv0743c 0.53 +1.1
834,182 + Rv0743c 0.53 +0.5
834,182 + Rv0743c 0.53 +0.3
834,183 - Rv0743c 0.53 +0.7
834,183 - Rv0743c 0.53 +1.1
834,183 - Rv0743c 0.53 +0.8
834,186 + Rv0743c 0.54 -1.4
834,186 + Rv0743c 0.54 -1.6
834,186 + Rv0743c 0.54 -0.9
834,187 - Rv0743c 0.54 +0.6
834,187 - Rv0743c 0.54 -2.0
834,187 - Rv0743c 0.54 -1.1
834,187 - Rv0743c 0.54 +0.8
834,199 + Rv0743c 0.56 +3.9
834,327 + Rv0743c 0.79 -1.3
834,328 - Rv0743c 0.79 +0.2
834,373 - Rv0743c 0.87 -0.8
834,524 + Rv0744c 0.17 -0.0
834,639 + Rv0744c 0.39 +0.8
834,670 + Rv0744c 0.45 -0.2
834,909 - +0.4
835,016 + +1.5
835,017 - +1.2
835,060 + +0.8
835,061 - +1.0
835,130 - +0.6
835,222 + Rv0745 0.13 +0.2

Or see this region's nucleotide sequence