Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0631c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0630c and Rv0631c overlap by 1 nucleotidesRv0631c and Rv0632c are separated by 276 nucleotides Rv0630c: Rv0630c - Probable exonuclease V (beta chain) RecB (exodeoxyribonuclease V beta chain)(exodeoxyribonuclease V polypeptide) (chi-specific endonuclease), at 721,729 to 725,013 Rv0630c Rv0631c: Rv0631c - Probable exonuclease V (gamma chain) RecC (exodeoxyribonuclease V gamma chain)(exodeoxyribonuclease V polypeptide), at 725,013 to 728,306 Rv0631c Rv0632c: Rv0632c - Probable enoyl-CoA hydratase EchA3 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase), at 728,583 to 729,278 Rv0632c Position (kb) 725 726 727 728 729Strain fitness (log2 ratio) -1 0 1 2 3 4at 724.097 kb on + strand, within Rv0630cat 724.098 kb on - strand, within Rv0630cat 724.490 kb on + strand, within Rv0630cat 724.535 kb on + strand, within Rv0630cat 724.536 kb on - strand, within Rv0630cat 725.315 kb on - strandat 725.503 kb on + strand, within Rv0631cat 725.852 kb on - strand, within Rv0631cat 726.588 kb on - strand, within Rv0631cat 727.160 kb on - strand, within Rv0631cat 727.160 kb on - strand, within Rv0631cat 727.316 kb on + strand, within Rv0631cat 727.316 kb on + strand, within Rv0631cat 727.861 kb on + strand, within Rv0631cat 727.862 kb on - strand, within Rv0631cat 728.360 kb on - strandat 728.360 kb on - strandat 728.360 kb on - strandat 728.540 kb on + strandat 728.585 kb on - strandat 728.908 kb on + strand, within Rv0632cat 728.909 kb on - strand, within Rv0632cat 729.020 kb on - strand, within Rv0632cat 729.257 kb on + strandat 729.260 kb on - strandat 729.260 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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724,097 + Rv0630c 0.72 +0.6
724,098 - Rv0630c 0.72 +1.6
724,490 + Rv0630c 0.84 -1.3
724,535 + Rv0630c 0.85 -0.3
724,536 - Rv0630c 0.85 -0.4
725,315 - -0.6
725,503 + Rv0631c 0.15 +3.8
725,852 - Rv0631c 0.25 +1.0
726,588 - Rv0631c 0.48 +1.7
727,160 - Rv0631c 0.65 -0.3
727,160 - Rv0631c 0.65 +1.2
727,316 + Rv0631c 0.70 +0.2
727,316 + Rv0631c 0.70 +0.1
727,861 + Rv0631c 0.86 +0.2
727,862 - Rv0631c 0.86 +0.2
728,360 - -0.5
728,360 - -0.6
728,360 - -1.0
728,540 + -0.7
728,585 - -0.3
728,908 + Rv0632c 0.47 +0.8
728,909 - Rv0632c 0.47 +1.1
729,020 - Rv0632c 0.63 -0.3
729,257 + +1.0
729,260 - -0.7
729,260 - +0.4

Or see this region's nucleotide sequence