Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv0425c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv0423c and Rv0424c are separated by 151 nucleotidesRv0424c and Rv0425c are separated by 49 nucleotidesRv0425c and Rv0426c are separated by 51 nucleotidesRv0426c and Rv0427c are separated by 200 nucleotides Rv0423c: Rv0423c - Probable thiamine biosynthesis protein ThiC, at 508,582 to 510,225 Rv0423c Rv0424c: Rv0424c - Hypothetical protein, at 510,377 to 510,652 Rv0424c Rv0425c: Rv0425c - Possible metal cation transporting P-type ATPase CtpH, at 510,702 to 515,321 Rv0425c Rv0426c: Rv0426c - Possible transmembrane protein, at 515,373 to 515,816 Rv0426c Rv0427c: Rv0427c - Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI), at 516,017 to 516,892 Rv0427c Position (kb) 510 511 512 513 514 515 516Strain fitness (log2 ratio) -2 -1 0 1at 510.238 kb on - strandat 510.430 kb on + strand, within Rv0424cat 510.430 kb on + strand, within Rv0424cat 510.442 kb on + strand, within Rv0424cat 510.442 kb on + strand, within Rv0424cat 510.442 kb on + strand, within Rv0424cat 510.516 kb on + strand, within Rv0424cat 510.516 kb on + strand, within Rv0424cat 510.516 kb on + strand, within Rv0424cat 510.516 kb on + strand, within Rv0424cat 510.517 kb on - strand, within Rv0424cat 510.517 kb on - strand, within Rv0424cat 510.517 kb on - strand, within Rv0424cat 510.519 kb on + strand, within Rv0424cat 510.519 kb on + strand, within Rv0424cat 510.520 kb on - strand, within Rv0424cat 510.548 kb on - strand, within Rv0424cat 510.580 kb on + strand, within Rv0424cat 510.580 kb on + strand, within Rv0424cat 510.638 kb on - strandat 510.638 kb on - strandat 510.715 kb on + strandat 510.798 kb on - strandat 510.798 kb on - strandat 511.397 kb on + strand, within Rv0425cat 511.686 kb on + strand, within Rv0425cat 511.687 kb on - strand, within Rv0425cat 512.502 kb on + strand, within Rv0425cat 512.604 kb on + strand, within Rv0425cat 512.822 kb on - strand, within Rv0425cat 513.026 kb on - strand, within Rv0425cat 513.225 kb on - strand, within Rv0425cat 513.225 kb on - strand, within Rv0425cat 513.701 kb on - strand, within Rv0425cat 513.773 kb on + strand, within Rv0425cat 515.204 kb on + strandat 515.375 kb on - strandat 515.550 kb on + strand, within Rv0426cat 515.660 kb on + strand, within Rv0426cat 515.660 kb on + strand, within Rv0426cat 515.661 kb on - strand, within Rv0426cat 515.847 kb on + strandat 516.199 kb on - strand, within Rv0427cat 516.230 kb on + strand, within Rv0427c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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510,238 - -0.2
510,430 + Rv0424c 0.19 -1.2
510,430 + Rv0424c 0.19 +0.3
510,442 + Rv0424c 0.24 -0.2
510,442 + Rv0424c 0.24 +0.7
510,442 + Rv0424c 0.24 -1.0
510,516 + Rv0424c 0.50 -0.3
510,516 + Rv0424c 0.50 -0.8
510,516 + Rv0424c 0.50 +0.4
510,516 + Rv0424c 0.50 -0.6
510,517 - Rv0424c 0.51 -1.9
510,517 - Rv0424c 0.51 -0.4
510,517 - Rv0424c 0.51 +0.3
510,519 + Rv0424c 0.51 +0.1
510,519 + Rv0424c 0.51 +0.9
510,520 - Rv0424c 0.52 +0.2
510,548 - Rv0424c 0.62 -0.0
510,580 + Rv0424c 0.74 -0.8
510,580 + Rv0424c 0.74 -0.1
510,638 - +0.3
510,638 - -0.6
510,715 + -0.7
510,798 - +1.7
510,798 - +0.6
511,397 + Rv0425c 0.15 +0.7
511,686 + Rv0425c 0.21 +0.2
511,687 - Rv0425c 0.21 -0.4
512,502 + Rv0425c 0.39 +0.0
512,604 + Rv0425c 0.41 -1.8
512,822 - Rv0425c 0.46 +1.2
513,026 - Rv0425c 0.50 -1.2
513,225 - Rv0425c 0.55 -0.5
513,225 - Rv0425c 0.55 -0.3
513,701 - Rv0425c 0.65 -0.4
513,773 + Rv0425c 0.66 -0.3
515,204 + -0.0
515,375 - -0.0
515,550 + Rv0426c 0.40 +0.3
515,660 + Rv0426c 0.65 -2.1
515,660 + Rv0426c 0.65 -1.9
515,661 - Rv0426c 0.65 -2.0
515,847 + -1.3
516,199 - Rv0427c 0.21 +0.7
516,230 + Rv0427c 0.24 +0.8

Or see this region's nucleotide sequence