Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2322c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2320c and Rv2321c are separated by 0 nucleotidesRv2321c and Rv2322c overlap by 1 nucleotidesRv2322c and Rv2323c overlap by 4 nucleotidesRv2323c and Rv2324 are separated by 64 nucleotides Rv2320c: Rv2320c - Probable cationic amino acid transport integral membrane protein RocE, at 2,592,723 to 2,594,153 Rv2320c Rv2321c: Rv2321c - Probable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase), at 2,594,154 to 2,594,699 Rv2321c Rv2322c: Rv2322c - Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase), at 2,594,699 to 2,595,364 Rv2322c Rv2323c: Rv2323c - Conserved protein, at 2,595,361 to 2,596,269 Rv2323c Rv2324: Rv2324 - Probable transcriptional regulatory protein (probably AsnC-family), at 2,596,334 to 2,596,780 Rv2324 Position (kb) 2594 2595 2596Strain fitness (log2 ratio) -2 -1 0 1 2at 2593.744 kb on + strand, within Rv2320cat 2593.744 kb on + strand, within Rv2320cat 2594.008 kb on - strand, within Rv2320cat 2594.155 kb on + strandat 2594.156 kb on - strandat 2594.257 kb on + strand, within Rv2321cat 2595.229 kb on - strand, within Rv2322cat 2595.603 kb on + strand, within Rv2323cat 2595.621 kb on - strand, within Rv2323cat 2595.869 kb on + strand, within Rv2323cat 2595.870 kb on - strand, within Rv2323cat 2595.957 kb on - strand, within Rv2323cat 2595.957 kb on - strand, within Rv2323cat 2595.957 kb on - strand, within Rv2323cat 2596.020 kb on - strand, within Rv2323cat 2596.020 kb on - strand, within Rv2323cat 2596.104 kb on - strand, within Rv2323cat 2596.177 kb on + strand, within Rv2323cat 2596.178 kb on - strand, within Rv2323cat 2596.178 kb on - strand, within Rv2323cat 2596.178 kb on - strand, within Rv2323cat 2596.178 kb on - strand, within Rv2323cat 2596.317 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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2,593,744 + Rv2320c 0.71 -1.7
2,593,744 + Rv2320c 0.71 +1.7
2,594,008 - Rv2320c 0.90 +0.0
2,594,155 + -1.8
2,594,156 - +1.2
2,594,257 + Rv2321c 0.19 -0.4
2,595,229 - Rv2322c 0.80 +0.4
2,595,603 + Rv2323c 0.27 -0.1
2,595,621 - Rv2323c 0.29 +0.3
2,595,869 + Rv2323c 0.56 +1.0
2,595,870 - Rv2323c 0.56 +0.0
2,595,957 - Rv2323c 0.66 -0.4
2,595,957 - Rv2323c 0.66 +1.9
2,595,957 - Rv2323c 0.66 -0.0
2,596,020 - Rv2323c 0.72 +0.3
2,596,020 - Rv2323c 0.72 -1.5
2,596,104 - Rv2323c 0.82 +0.8
2,596,177 + Rv2323c 0.90 -0.8
2,596,178 - Rv2323c 0.90 -0.3
2,596,178 - Rv2323c 0.90 +0.1
2,596,178 - Rv2323c 0.90 +0.5
2,596,178 - Rv2323c 0.90 +1.4
2,596,317 - +1.0

Or see this region's nucleotide sequence