Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2232

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2231c and Rv2231A are separated by 36 nucleotidesRv2231A and Rv2231B are separated by 45 nucleotidesRv2231B and Rv2232 overlap by 106 nucleotidesRv2232 and Rv2234 overlap by 8 nucleotidesRv2234 and Rv2235 overlap by 1 nucleotides Rv2231c: Rv2231c - Possible aminotransferase CobC, at 2,504,605 to 2,505,699 Rv2231c Rv2231A: Rv2231A - Possible toxin VapC16, at 2,505,736 to 2,506,161 Rv2231A Rv2231B: Rv2231B - Possible antitoxin VapB16, at 2,506,207 to 2,506,383 Rv2231B Rv2232: Rv2232 - Protein tyrosine kinase transcriptional regulatory protein PtkA, at 2,506,278 to 2,507,153 Rv2232 Rv2234: Rv2234 - Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase), at 2,507,146 to 2,507,637 Rv2234 Rv2235: Rv2235 - Probable conserved transmembrane protein, at 2,507,637 to 2,508,452 Rv2235 Position (kb) 2506 2507 2508Strain fitness (log2 ratio) -2 -1 0 1 2 3at 2505.641 kb on - strandat 2505.641 kb on - strandat 2505.664 kb on + strandat 2505.665 kb on - strandat 2505.747 kb on + strandat 2505.748 kb on - strandat 2505.748 kb on - strandat 2505.915 kb on - strand, within Rv2231Aat 2505.915 kb on - strand, within Rv2231Aat 2506.076 kb on - strand, within Rv2231Aat 2506.371 kb on - strandat 2506.570 kb on + strand, within Rv2232at 2506.708 kb on + strand, within Rv2232at 2507.144 kb on - strandat 2507.179 kb on - strandat 2507.294 kb on + strand, within Rv2234at 2507.294 kb on + strand, within Rv2234at 2507.528 kb on - strand, within Rv2234at 2507.528 kb on - strand, within Rv2234at 2507.530 kb on + strand, within Rv2234

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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2,505,641 - +2.6
2,505,641 - +1.8
2,505,664 + +0.0
2,505,665 - -0.0
2,505,747 + -1.1
2,505,748 - -1.6
2,505,748 - +0.0
2,505,915 - Rv2231A 0.42 -0.2
2,505,915 - Rv2231A 0.42 +1.5
2,506,076 - Rv2231A 0.80 -1.3
2,506,371 - +0.2
2,506,570 + Rv2232 0.33 +0.8
2,506,708 + Rv2232 0.49 +0.5
2,507,144 - +3.6
2,507,179 - +0.2
2,507,294 + Rv2234 0.30 +0.2
2,507,294 + Rv2234 0.30 -2.1
2,507,528 - Rv2234 0.78 +0.2
2,507,528 - Rv2234 0.78 +1.0
2,507,530 + Rv2234 0.78 -1.7

Or see this region's nucleotide sequence