Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1598c

Experiment: 7H9 with Ofloxacin 0.8 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1596 and Rv1597 are separated by 48 nucleotidesRv1597 and Rv1598c are separated by 20 nucleotidesRv1598c and Rv1599 are separated by 99 nucleotides Rv1596: Rv1596 - Probable nicotinate-nucleotide pyrophosphatase NadC, at 1,797,388 to 1,798,245 Rv1596 Rv1597: Rv1597 - Hypothetical protein, at 1,798,294 to 1,799,052 Rv1597 Rv1598c: Rv1598c - Conserved protein, at 1,799,073 to 1,799,483 Rv1598c Rv1599: Rv1599 - Probable histidinol dehydrogenase HisD (HDH), at 1,799,583 to 1,800,899 Rv1599 Position (kb) 1799 1800Strain fitness (log2 ratio) -1 0 1 2at 1798.239 kb on + strandat 1798.239 kb on + strandat 1798.243 kb on + strandat 1798.243 kb on + strandat 1798.244 kb on - strandat 1798.244 kb on - strandat 1798.268 kb on - strandat 1798.268 kb on - strandat 1798.282 kb on - strandat 1798.452 kb on - strand, within Rv1597at 1798.452 kb on - strand, within Rv1597at 1798.546 kb on - strand, within Rv1597at 1798.546 kb on - strand, within Rv1597at 1798.708 kb on + strand, within Rv1597at 1798.709 kb on - strand, within Rv1597at 1798.796 kb on - strand, within Rv1597at 1798.900 kb on + strand, within Rv1597at 1798.901 kb on - strand, within Rv1597at 1799.069 kb on - strandat 1799.253 kb on - strand, within Rv1598cat 1799.253 kb on - strand, within Rv1598cat 1799.253 kb on - strand, within Rv1598cat 1799.402 kb on - strand, within Rv1598cat 1799.511 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ofloxacin 0.8 ug/mL
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1,798,239 + +0.3
1,798,239 + -1.5
1,798,243 + -0.2
1,798,243 + +0.5
1,798,244 - +0.6
1,798,244 - -0.8
1,798,268 - -0.0
1,798,268 - -0.1
1,798,282 - -0.0
1,798,452 - Rv1597 0.21 +0.1
1,798,452 - Rv1597 0.21 -0.1
1,798,546 - Rv1597 0.33 +0.7
1,798,546 - Rv1597 0.33 -0.2
1,798,708 + Rv1597 0.55 -0.1
1,798,709 - Rv1597 0.55 +1.0
1,798,796 - Rv1597 0.66 +0.0
1,798,900 + Rv1597 0.80 +1.3
1,798,901 - Rv1597 0.80 -0.3
1,799,069 - +2.0
1,799,253 - Rv1598c 0.44 -0.4
1,799,253 - Rv1598c 0.44 -0.7
1,799,253 - Rv1598c 0.44 +0.3
1,799,402 - Rv1598c 0.80 -0.7
1,799,511 - -0.0

Or see this region's nucleotide sequence