Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3886c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3885c and Rv3886c overlap by 4 nucleotidesRv3886c and Rv3887c overlap by 16 nucleotides Rv3885c: Rv3885c - ESX conserved component EccE2. ESX-2 type VII secretion system protein. Possible membrane protein., at 4,366,908 to 4,368,521 Rv3885c Rv3886c: Rv3886c - Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-2), at 4,368,518 to 4,370,170 Rv3886c Rv3887c: Rv3887c - ESX conserved component EccD2. ESX-2 type VII secretion system protein. Probable transmembrane protein., at 4,370,155 to 4,371,684 Rv3887c Position (kb) 4368 4369 4370 4371Strain fitness (log2 ratio) -1 0 1 2at 4367.740 kb on + strand, within Rv3885cat 4368.168 kb on + strand, within Rv3885cat 4368.333 kb on + strand, within Rv3885cat 4368.370 kb on - strandat 4368.415 kb on - strandat 4368.598 kb on + strandat 4368.695 kb on - strand, within Rv3886cat 4368.852 kb on + strand, within Rv3886cat 4368.853 kb on - strand, within Rv3886cat 4368.887 kb on - strand, within Rv3886cat 4368.887 kb on - strand, within Rv3886cat 4369.053 kb on + strand, within Rv3886cat 4369.054 kb on - strand, within Rv3886cat 4369.131 kb on + strand, within Rv3886cat 4369.131 kb on + strand, within Rv3886cat 4369.132 kb on - strand, within Rv3886cat 4369.132 kb on - strand, within Rv3886cat 4369.213 kb on - strand, within Rv3886cat 4369.724 kb on + strand, within Rv3886cat 4369.812 kb on + strand, within Rv3886cat 4370.204 kb on - strandat 4370.383 kb on - strand, within Rv3887cat 4370.383 kb on - strand, within Rv3887cat 4370.383 kb on - strand, within Rv3887cat 4370.439 kb on - strand, within Rv3887cat 4370.583 kb on + strand, within Rv3887cat 4370.583 kb on + strand, within Rv3887cat 4370.584 kb on - strand, within Rv3887cat 4370.830 kb on + strand, within Rv3887cat 4370.871 kb on + strand, within Rv3887cat 4370.872 kb on - strand, within Rv3887c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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4,367,740 + Rv3885c 0.52 -0.8
4,368,168 + Rv3885c 0.78 -1.7
4,368,333 + Rv3885c 0.88 -0.4
4,368,370 - +0.2
4,368,415 - -0.4
4,368,598 + +1.0
4,368,695 - Rv3886c 0.11 +1.0
4,368,852 + Rv3886c 0.20 +0.2
4,368,853 - Rv3886c 0.20 +0.9
4,368,887 - Rv3886c 0.22 +0.9
4,368,887 - Rv3886c 0.22 -0.0
4,369,053 + Rv3886c 0.32 +2.4
4,369,054 - Rv3886c 0.32 +1.1
4,369,131 + Rv3886c 0.37 +1.0
4,369,131 + Rv3886c 0.37 -1.5
4,369,132 - Rv3886c 0.37 +1.1
4,369,132 - Rv3886c 0.37 +0.0
4,369,213 - Rv3886c 0.42 -1.3
4,369,724 + Rv3886c 0.73 +1.8
4,369,812 + Rv3886c 0.78 +0.0
4,370,204 - -1.7
4,370,383 - Rv3887c 0.15 -0.8
4,370,383 - Rv3887c 0.15 -1.7
4,370,383 - Rv3887c 0.15 -0.6
4,370,439 - Rv3887c 0.19 -0.4
4,370,583 + Rv3887c 0.28 -0.4
4,370,583 + Rv3887c 0.28 +1.4
4,370,584 - Rv3887c 0.28 -1.0
4,370,830 + Rv3887c 0.44 -0.4
4,370,871 + Rv3887c 0.47 -0.6
4,370,872 - Rv3887c 0.47 -1.3

Or see this region's nucleotide sequence