Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3572

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3571 and Rv3572 are separated by 17 nucleotidesRv3572 and Rv3573c are separated by 35 nucleotides Rv3571: Rv3571 - Reductase component of 3-ketosteroid-9-alpha-hydroxylase KshB, at 4,012,417 to 4,013,493 Rv3571 Rv3572: Rv3572 - Unknown protein, at 4,013,511 to 4,014,041 Rv3572 Rv3573c: Rv3573c - Probable acyl-CoA dehydrogenase FadE34, at 4,014,077 to 4,016,212 Rv3573c Position (kb) 4013 4014 4015Strain fitness (log2 ratio) -1 0 1 2 3at 4012.615 kb on - strand, within Rv3571at 4012.960 kb on + strand, within Rv3571at 4012.961 kb on - strand, within Rv3571at 4013.048 kb on - strand, within Rv3571at 4013.386 kb on - strandat 4013.483 kb on - strandat 4013.560 kb on + strandat 4013.788 kb on - strand, within Rv3572at 4013.862 kb on + strand, within Rv3572at 4013.862 kb on + strand, within Rv3572at 4013.863 kb on - strand, within Rv3572at 4013.863 kb on - strand, within Rv3572at 4013.889 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4013.966 kb on + strand, within Rv3572at 4014.043 kb on + strandat 4014.642 kb on + strand, within Rv3573cat 4014.643 kb on - strand, within Rv3573cat 4014.643 kb on - strand, within Rv3573cat 4014.647 kb on - strand, within Rv3573cat 4014.647 kb on - strand, within Rv3573c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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4,012,615 - Rv3571 0.18 +0.7
4,012,960 + Rv3571 0.50 -0.3
4,012,961 - Rv3571 0.51 +0.0
4,013,048 - Rv3571 0.59 -0.4
4,013,386 - +2.3
4,013,483 - +0.1
4,013,560 + +2.9
4,013,788 - Rv3572 0.52 -0.5
4,013,862 + Rv3572 0.66 +0.5
4,013,862 + Rv3572 0.66 -0.3
4,013,863 - Rv3572 0.66 -1.2
4,013,863 - Rv3572 0.66 +0.9
4,013,889 + Rv3572 0.71 -0.6
4,013,966 + Rv3572 0.86 -0.7
4,013,966 + Rv3572 0.86 +0.7
4,013,966 + Rv3572 0.86 -0.8
4,013,966 + Rv3572 0.86 -0.1
4,014,043 + -0.5
4,014,642 + Rv3573c 0.26 -0.2
4,014,643 - Rv3573c 0.26 +1.6
4,014,643 - Rv3573c 0.26 -0.6
4,014,647 - Rv3573c 0.27 -0.8
4,014,647 - Rv3573c 0.27 -0.6

Or see this region's nucleotide sequence