Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv3342

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv3341 and Rv3342 overlap by 4 nucleotidesRv3342 and Rv3343c are separated by 8 nucleotides Rv3341: Rv3341 - Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA), at 3,727,488 to 3,728,627 Rv3341 Rv3342: Rv3342 - Possible methyltransferase (methylase), at 3,728,624 to 3,729,355 Rv3342 Rv3343c: Rv3343c - PPE family protein PPE54, at 3,729,364 to 3,736,935 Rv3343c Position (kb) 3728 3729 3730Strain fitness (log2 ratio) -1 0 1at 3728.699 kb on + strand, within Rv3342at 3729.134 kb on - strand, within Rv3342at 3729.212 kb on + strand, within Rv3342at 3729.468 kb on - strandat 3729.938 kb on - strandat 3730.018 kb on - strandat 3730.058 kb on - strandat 3730.353 kb on - strand, within Rv3343c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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3,728,699 + Rv3342 0.10 -0.4
3,729,134 - Rv3342 0.70 +1.1
3,729,212 + Rv3342 0.80 +0.1
3,729,468 - +0.1
3,729,938 - +1.3
3,730,018 - +0.4
3,730,058 - -0.5
3,730,353 - Rv3343c 0.13 -0.4

Or see this region's nucleotide sequence