Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2918c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2917 and Rv2918c are separated by 10 nucleotidesRv2918c and Rv2919c are separated by 57 nucleotidesRv2919c and Rv2920c overlap by 4 nucleotides Rv2917: Rv2917 - Conserved hypothetical alanine and arginine rich protein, at 3,226,363 to 3,228,243 Rv2917 Rv2918c: Rv2918c - Probable [protein-PII] uridylyltransferase GlnD (PII uridylyl-transferase) (uridylyl removing enzyme) (UTASE), at 3,228,254 to 3,230,680 Rv2918c Rv2919c: Rv2919c - Probable nitrogen regulatory protein P-II GlnB, at 3,230,738 to 3,231,076 Rv2919c Rv2920c: Rv2920c - Probable ammonium-transport integral membrane protein Amt, at 3,231,073 to 3,232,506 Rv2920c Position (kb) 3228 3229 3230 3231Strain fitness (log2 ratio) -2 -1 0 1at 3227.464 kb on - strand, within Rv2917at 3227.464 kb on - strand, within Rv2917at 3227.558 kb on - strand, within Rv2917at 3227.558 kb on - strand, within Rv2917at 3227.703 kb on + strand, within Rv2917at 3227.905 kb on + strand, within Rv2917at 3228.395 kb on - strandat 3228.548 kb on - strand, within Rv2918cat 3228.593 kb on + strand, within Rv2918cat 3228.774 kb on - strand, within Rv2918cat 3228.845 kb on + strand, within Rv2918cat 3228.877 kb on + strand, within Rv2918cat 3228.918 kb on + strand, within Rv2918cat 3228.919 kb on - strand, within Rv2918cat 3229.136 kb on + strand, within Rv2918cat 3229.529 kb on + strand, within Rv2918cat 3229.533 kb on - strand, within Rv2918cat 3229.533 kb on - strand, within Rv2918cat 3230.940 kb on + strand, within Rv2919cat 3231.103 kb on + strandat 3231.103 kb on + strandat 3231.104 kb on - strandat 3231.105 kb on + strandat 3231.105 kb on + strandat 3231.106 kb on - strandat 3231.362 kb on + strand, within Rv2920cat 3231.646 kb on - strand, within Rv2920c

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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3,227,464 - Rv2917 0.59 -0.2
3,227,464 - Rv2917 0.59 -1.3
3,227,558 - Rv2917 0.64 -1.0
3,227,558 - Rv2917 0.64 -0.3
3,227,703 + Rv2917 0.71 -0.0
3,227,905 + Rv2917 0.82 +1.0
3,228,395 - -1.1
3,228,548 - Rv2918c 0.12 +1.7
3,228,593 + Rv2918c 0.14 +0.7
3,228,774 - Rv2918c 0.21 +1.4
3,228,845 + Rv2918c 0.24 -1.0
3,228,877 + Rv2918c 0.26 -1.1
3,228,918 + Rv2918c 0.27 +1.7
3,228,919 - Rv2918c 0.27 +1.0
3,229,136 + Rv2918c 0.36 +1.3
3,229,529 + Rv2918c 0.53 -0.7
3,229,533 - Rv2918c 0.53 +0.3
3,229,533 - Rv2918c 0.53 -0.2
3,230,940 + Rv2919c 0.60 -0.6
3,231,103 + +0.5
3,231,103 + +0.0
3,231,104 - -0.1
3,231,105 + -1.8
3,231,105 + -0.7
3,231,106 - +0.5
3,231,362 + Rv2920c 0.20 +0.1
3,231,646 - Rv2920c 0.40 -0.7

Or see this region's nucleotide sequence