Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2710

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2707 and Rv2708c are separated by 0 nucleotidesRv2708c and Rv2709 are separated by 42 nucleotidesRv2709 and Rv2710 are separated by 175 nucleotidesRv2710 and Rv2711 are separated by 132 nucleotidesRv2711 and Rv2712c are separated by 12 nucleotides Rv2707: Rv2707 - Probable conserved transmembrane alanine and leucine rich protein, at 3,020,573 to 3,021,547 Rv2707 Rv2708c: Rv2708c - Conserved hypothetical protein, at 3,021,548 to 3,021,796 Rv2708c Rv2709: Rv2709 - Probable conserved transmembrane protein, at 3,021,839 to 3,022,285 Rv2709 Rv2710: Rv2710 - RNA polymerase sigma factor SigB, at 3,022,461 to 3,023,432 Rv2710 Rv2711: Rv2711 - Iron-dependent repressor and activator IdeR, at 3,023,565 to 3,024,257 Rv2711 Rv2712c: Rv2712c - Hypothetical protein, at 3,024,270 to 3,025,328 Rv2712c Position (kb) 3022 3023 3024Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 3021.497 kb on + strandat 3021.497 kb on + strandat 3021.498 kb on - strandat 3021.498 kb on - strandat 3021.498 kb on - strandat 3021.570 kb on + strandat 3021.570 kb on + strandat 3021.570 kb on + strandat 3021.702 kb on + strand, within Rv2708cat 3021.712 kb on - strand, within Rv2708cat 3021.763 kb on + strand, within Rv2708cat 3021.764 kb on - strand, within Rv2708cat 3021.787 kb on + strandat 3021.788 kb on - strandat 3021.788 kb on - strandat 3021.788 kb on - strandat 3021.850 kb on + strandat 3021.850 kb on + strandat 3021.850 kb on + strandat 3021.850 kb on + strandat 3021.850 kb on + strandat 3021.850 kb on + strandat 3021.851 kb on - strandat 3021.959 kb on + strand, within Rv2709at 3021.959 kb on + strand, within Rv2709at 3021.960 kb on - strand, within Rv2709at 3021.988 kb on + strand, within Rv2709at 3021.988 kb on + strand, within Rv2709at 3021.988 kb on + strand, within Rv2709at 3021.988 kb on + strand, within Rv2709at 3021.989 kb on - strand, within Rv2709at 3021.989 kb on - strand, within Rv2709at 3021.989 kb on - strand, within Rv2709at 3021.992 kb on + strand, within Rv2709at 3022.773 kb on + strand, within Rv2710at 3023.421 kb on + strandat 3023.454 kb on + strandat 3023.464 kb on + strandat 3023.490 kb on + strandat 3024.271 kb on + strandat 3024.272 kb on - strand

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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3,021,497 + +0.1
3,021,497 + +2.3
3,021,498 - -0.2
3,021,498 - +1.0
3,021,498 - -2.2
3,021,570 + +2.3
3,021,570 + -1.4
3,021,570 + +0.2
3,021,702 + Rv2708c 0.62 +1.0
3,021,712 - Rv2708c 0.66 -1.4
3,021,763 + Rv2708c 0.86 -2.3
3,021,764 - Rv2708c 0.87 +1.3
3,021,787 + -1.1
3,021,788 - -1.3
3,021,788 - +0.1
3,021,788 - -1.8
3,021,850 + -0.8
3,021,850 + -1.4
3,021,850 + +0.2
3,021,850 + -0.7
3,021,850 + -0.3
3,021,850 + -0.1
3,021,851 - +0.3
3,021,959 + Rv2709 0.27 -3.0
3,021,959 + Rv2709 0.27 -1.1
3,021,960 - Rv2709 0.27 -1.2
3,021,988 + Rv2709 0.33 -2.7
3,021,988 + Rv2709 0.33 -1.4
3,021,988 + Rv2709 0.33 -2.7
3,021,988 + Rv2709 0.33 -3.0
3,021,989 - Rv2709 0.34 +1.3
3,021,989 - Rv2709 0.34 -0.0
3,021,989 - Rv2709 0.34 -2.3
3,021,992 + Rv2709 0.34 +0.4
3,022,773 + Rv2710 0.32 -0.6
3,023,421 + +0.6
3,023,454 + -0.5
3,023,464 + +2.3
3,023,490 + -0.6
3,024,271 + -0.2
3,024,272 - +0.9

Or see this region's nucleotide sequence