Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2462c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2460c and Rv2461c overlap by 4 nucleotidesRv2461c and Rv2462c are separated by 116 nucleotidesRv2462c and GFF2562 are separated by 39 nucleotidesGFF2562 and GFF2563 are separated by 136 nucleotidesGFF2563 and Rv2463 are separated by 43 nucleotides Rv2460c: Rv2460c - Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2), at 2,762,531 to 2,763,175 Rv2460c Rv2461c: Rv2461c - Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP), at 2,763,172 to 2,763,774 Rv2461c Rv2462c: Rv2462c - Probable trigger factor (TF) protein Tig, at 2,763,891 to 2,765,291 Rv2462c GFF2562 - tRNA-Pro, at 2,765,331 to 2,765,404 GFF2562 GFF2563 - tRNA-Gly, at 2,765,541 to 2,765,611 GFF2563 Rv2463: Rv2463 - Probable esterase/lipase LipP, at 2,765,655 to 2,766,839 Rv2463 Position (kb) 2763 2764 2765 2766Strain fitness (log2 ratio) -2 -1 0 1at 2763.887 kb on - strandat 2763.887 kb on - strandat 2764.388 kb on - strand, within Rv2462cat 2764.388 kb on - strand, within Rv2462cat 2764.536 kb on + strand, within Rv2462cat 2764.853 kb on + strand, within Rv2462cat 2764.854 kb on - strand, within Rv2462cat 2764.857 kb on + strand, within Rv2462cat 2764.857 kb on + strand, within Rv2462cat 2764.857 kb on + strand, within Rv2462cat 2764.994 kb on - strand, within Rv2462cat 2765.198 kb on - strandat 2765.516 kb on + strandat 2765.516 kb on + strandat 2765.536 kb on + strandat 2765.536 kb on + strandat 2765.536 kb on + strandat 2765.536 kb on + strandat 2765.704 kb on + strandat 2766.129 kb on + strand, within Rv2463at 2766.189 kb on - strand, within Rv2463at 2766.201 kb on + strand, within Rv2463at 2766.202 kb on - strand, within Rv2463at 2766.287 kb on - strand, within Rv2463

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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2,763,887 - -0.7
2,763,887 - -0.1
2,764,388 - Rv2462c 0.35 +1.6
2,764,388 - Rv2462c 0.35 +0.3
2,764,536 + Rv2462c 0.46 -0.5
2,764,853 + Rv2462c 0.69 -0.1
2,764,854 - Rv2462c 0.69 +0.4
2,764,857 + Rv2462c 0.69 -0.6
2,764,857 + Rv2462c 0.69 +1.7
2,764,857 + Rv2462c 0.69 -0.5
2,764,994 - Rv2462c 0.79 +0.5
2,765,198 - -0.9
2,765,516 + +0.2
2,765,516 + -0.1
2,765,536 + -0.9
2,765,536 + -0.8
2,765,536 + -1.0
2,765,536 + -0.5
2,765,704 + +0.3
2,766,129 + Rv2463 0.40 -0.3
2,766,189 - Rv2463 0.45 -0.7
2,766,201 + Rv2463 0.46 +0.5
2,766,202 - Rv2463 0.46 -0.6
2,766,287 - Rv2463 0.53 -1.9

Or see this region's nucleotide sequence