Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv2383c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv2382c and Rv2383c overlap by 11 nucleotidesRv2383c and Rv2384 are separated by 98 nucleotides Rv2382c: Rv2382c - Polyketide synthetase MbtC (polyketide synthase), at 2,670,269 to 2,671,603 Rv2382c Rv2383c: Rv2383c - Phenyloxazoline synthase MbtB (phenyloxazoline synthetase), at 2,671,593 to 2,675,837 Rv2383c Rv2384: Rv2384 - Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase, at 2,675,936 to 2,677,633 Rv2384 Position (kb) 2671 2672 2673 2674 2675 2676Strain fitness (log2 ratio) -3 -2 -1 0 1 2at 2671.123 kb on - strand, within Rv2382cat 2671.301 kb on + strand, within Rv2382cat 2671.648 kb on + strandat 2673.500 kb on - strand, within Rv2383cat 2673.952 kb on + strand, within Rv2383cat 2673.952 kb on + strand, within Rv2383cat 2674.515 kb on + strand, within Rv2383cat 2674.583 kb on - strand, within Rv2383cat 2675.054 kb on - strand, within Rv2383cat 2675.054 kb on - strand, within Rv2383cat 2675.089 kb on + strand, within Rv2383cat 2675.122 kb on + strand, within Rv2383cat 2675.163 kb on + strand, within Rv2383cat 2675.825 kb on + strandat 2675.826 kb on - strandat 2675.881 kb on - strandat 2675.909 kb on + strandat 2676.624 kb on - strand, within Rv2384at 2676.680 kb on + strand, within Rv2384at 2676.680 kb on + strand, within Rv2384

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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2,671,123 - Rv2382c 0.64 +1.4
2,671,301 + Rv2382c 0.77 -0.3
2,671,648 + +0.1
2,673,500 - Rv2383c 0.45 -0.1
2,673,952 + Rv2383c 0.56 -0.0
2,673,952 + Rv2383c 0.56 +2.3
2,674,515 + Rv2383c 0.69 -0.4
2,674,583 - Rv2383c 0.70 -0.2
2,675,054 - Rv2383c 0.82 +1.3
2,675,054 - Rv2383c 0.82 +1.2
2,675,089 + Rv2383c 0.82 +2.3
2,675,122 + Rv2383c 0.83 +2.0
2,675,163 + Rv2383c 0.84 -2.8
2,675,825 + +0.7
2,675,826 - -0.7
2,675,881 - -0.1
2,675,909 + +1.0
2,676,624 - Rv2384 0.41 -0.9
2,676,680 + Rv2384 0.44 +2.3
2,676,680 + Rv2384 0.44 +2.3

Or see this region's nucleotide sequence