Strain Fitness in Mycobacterium tuberculosis H37Rv around Rv1730c

Experiment: 7H9 with Ethionamide 0.1 ug/mL

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Only strains with sufficient reads to estimate fitness are shown, but the strain fitness values are still rather noisy and may be biased towards zero. Strains near the edge of a gene are not shown as being associated with that gene (they are in grey). Strains in the central 10-90% of a gene are color coded by the insertion's strand. Usually, "+" means that the selectable marker is encoded on the forward strand, i.e., transcribed rightward.

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500 ntRv1729c and Rv1730c are separated by 122 nucleotidesRv1730c and Rv1731 are separated by 431 nucleotides Rv1729c: Rv1729c - Possible S-adenosylmethionine-dependent methyltransferase, at 1,954,631 to 1,955,569 Rv1729c Rv1730c: Rv1730c - Possible penicillin-binding protein, at 1,955,692 to 1,957,245 Rv1730c Rv1731: Rv1731 - Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2, at 1,957,677 to 1,959,233 Rv1731 Position (kb) 1955 1956 1957 1958Strain fitness (log2 ratio) -2 -1 0 1 2at 1954.878 kb on - strand, within Rv1729cat 1955.005 kb on - strand, within Rv1729cat 1955.005 kb on - strand, within Rv1729cat 1955.006 kb on + strand, within Rv1729cat 1955.006 kb on + strand, within Rv1729cat 1955.531 kb on - strandat 1955.693 kb on + strandat 1956.333 kb on + strand, within Rv1730cat 1956.693 kb on - strand, within Rv1730cat 1956.986 kb on + strand, within Rv1730cat 1957.370 kb on - strandat 1957.631 kb on + strandat 1957.676 kb on + strandat 1958.025 kb on + strand, within Rv1731at 1958.063 kb on + strand, within Rv1731at 1958.109 kb on + strand, within Rv1731at 1958.109 kb on + strand, within Rv1731at 1958.151 kb on + strand, within Rv1731at 1958.152 kb on - strand, within Rv1731at 1958.238 kb on + strand, within Rv1731

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Per-strain Table

Position Strand Gene LocusTag Fraction 7H9 with Ethionamide 0.1 ug/mL
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1,954,878 - Rv1729c 0.26 -1.0
1,955,005 - Rv1729c 0.40 -2.3
1,955,005 - Rv1729c 0.40 -0.3
1,955,006 + Rv1729c 0.40 +2.0
1,955,006 + Rv1729c 0.40 -0.5
1,955,531 - +0.3
1,955,693 + -0.3
1,956,333 + Rv1730c 0.41 +1.3
1,956,693 - Rv1730c 0.64 +0.9
1,956,986 + Rv1730c 0.83 -0.6
1,957,370 - -1.2
1,957,631 + -2.3
1,957,676 + +0.1
1,958,025 + Rv1731 0.22 +1.8
1,958,063 + Rv1731 0.25 -0.7
1,958,109 + Rv1731 0.28 -0.8
1,958,109 + Rv1731 0.28 -0.3
1,958,151 + Rv1731 0.30 +0.2
1,958,152 - Rv1731 0.31 -1.4
1,958,238 + Rv1731 0.36 -0.0

Or see this region's nucleotide sequence